For example, recent British Society for Rheumatology guidelines on the management of SLE go into extensive detail on the importance of regular laboratory monitoring of hematologic, renal, and biochemical parameters--every 3 months in patients who are clinically quiet but serologically active, and every 6 months in those with inactive disease and no previous organ damage--but the guidelines make no mention of the skin clues to thrombotic vasculopathy
Conditions, such as noninflammatory vasculopathy
bleeding due to microangiopathy, antiribosomal-P antibody, anti NR-2 glutamate receptor antibody, and inflammatory cytokines are considered to play role in the pathophysiology (18,19,20).
1) Subsequently, the term fetal thrombotic vasculopathy
(FTV) was reserved for groups with 15 or more affected terminal villi per section (at least 2), revealing avascular villous morphology or villous stromal karyorrhexis.
Cardiac allograft vasculopathy
is characterized by diffuse and concentric arterial obstruction rather than the focal aspect of common atherosclerosis.
Taking place between 7-10 September 2017 in Barcelona, Spain, seven oral presentations of data from Bayer-sponsored studies regarding aflibercept will showcase the companys commitment to addressing the treatment of a variety of life-altering conditions, such as wet age-related macular degeneration (wet AMD/nAMD), polypoidal choroidal vasculopathy
(PCV, a variant of wet AMD), and the treatment of visual impairment due to diabetic macular edema (DME).
Years of clinical and subclinical haemolysis and vaso-occlusive episodes in sickle cell anaemia may lead to an obstructive pulmonary vasculopathy
with a gradual increase in pulmonary vascular resistance and RV afterload, reflected in a steady increase in RV mass index out of proportion to the chronic anaemia-induced RV preload (Naveen Qureshi et al).
When calcium accumulates in small subcutaneous vessels, an occlusive vasculopathy
is created within the dermis.
Mechanisms of ectopic calcification: implications for diabetic vasculopathy
Acute retinal necrosis (ARN), first described in 1971, is a clinical condition characterized by areas of retinal necrosis, occlusive vasculopathy
, vitritis, anterior chamber reaction, and optic neuritis.
9] The discrete histopathological findings were grouped into 15 main findings and four major pathological patterns for the purpose of statistical analysis:  (i) maternal vascular underperfusion (MUP) including non-marginal, recent, and organised infarction involving >10% of parenchyma, agglutination, placental syncytial (ST) knots, intervillous fibrin deposition involving more than 20% of the intervillous space, peri-villous fibrin deposition, villous hypoplasia, intervillous haematoma or retroplacental haematoma; (ii) fetal vascular underperfusion (FUP) including fetal vasculopathy
and/or avascular villi; (iii) inflammatory with villitis, chorioamnionitis or vasculitis lesions; (iv) others (stromal fibrosis and calcification).
In a separate study, Bayer said Aflibercept monotherapy has been found effective in polypoidal choroidal vasculopathy
(PCV), a subtype of wAMD highly prevalent in Asia.
The findings in the brain included focal minimal parasagittal and parietal pachygyria, glioneuronal heterotopias, neuronal migrational abnormalities, hypomyelination of central white matter, and mineralizing lenticulostriate vasculopathy
with focal gliosis in basal ganglia and thalamus.