hemophilia /he·mo·phil·ia/ (he″mo-fil´e-ah) a hereditary hemorrhagic diathesis due to deficiency of a blood coagulation factor.
vascular hemophilia.
hemophilia (bleeder's disease) (hē´mōfil´ē
),
hemophilia A classical h.; an X-linked recessive form due to deficiency of coagulation factor VIII.
hemophilia B Christmas disease; an X-linked recessive form due to deficiency of coagulation factor IX.
hemophilia C an autosomal disorder due to lack of coagulation factor XI; seen predominantly in persons of Jewish ancestry and characterized by minor bleeding, mild bruising, severe prolonged postsurgical bleeding, and abnormal clotting test times.
classical hemophilia h. A.
vascular hemophilia von Willebrand's disease.
| vascular hemophilia n. |
vascular hemophilia.
hemophilia (bleeder's disease) (hē´mōfil´ē
),n a sex-linked genetic disease manifested in males and characterized by severe hemorrhage.
hemophilia A (classic hemophilia),
n a hemorrhagic diathesis resulting from a deficiency of antihemophilic globulin (AHG); inherited as a recessive sex-linked characteristic and characterized by recurrent bouts of bleeding from even trivial injury. The coagulation time is prolonged, but the bleeding time is normal.
hemophilia B (Christmas disease, hemophilia II, hemophilioid state C),
n a hemorrhagic diathesis resulting from a deficiency of plasma thromboplastin component (PTC); transmitted as a sex-linked recessive characteristic and characterized clinically by the same manifestations as classic hemophilia. There is a delay in the generation of thromboplastin. The platelet count, bleeding time, tourniquet test, and thrombin and prothrombin times are normal.
hemophilia C (plasma thromboplastin antecedent [PTA] deficiency, Rosenthal's syndrome),
n a hemophilia-like condition believed to result from a deficiency of plasma thromboplastin antecedent (PTA), transmitted as a simple autosomal dominant trait and characterized by a moderate bleeding tendency after extraction of teeth or after tonsillectomy. Prothrombin consumption and thromboplastin generation are abnormal. See also factor XI.
hemophilia, classic,
n See hemophilia A.
hemophilia, vascular,
n a hereditary hemorrhagic disorder affecting both sexes and associated with a deficiency of antihemophilic globulin and vascular abnormalities characteristic of pseudohemophilia (von Willebrand disease). The bleeding time is prolonged, and severity of bleeding varies considerably among persons with this condition.
hemophilia
a condition characterized by impaired coagulability of the blood, and a strong tendency to bleed. See also deficiency of the following clotting factors, afibrinogenemia and hypoprothrombinemia, and proconvertin, stuart factor, plasma thromboplastin antecedent, hageman factor and fibrin stabilizing factor.
hemophilia A
classical hemophilia, due to deficiency of clotting factor VIII-C; occurs in dogs, horses and cats and is transmitted by the female to the male as a sex-linked recessive abnormality.
hemophilia B
a form similar to classical hemophilia but due to a deficiency of clotting factor IX; called also christmas disease and factor IX deficiency. Occurs in dogs and cats.
hemophilia C
in dogs an autosomal dominant form due to deficiency of clotting factor XI (plasma thromboplastin antecedent). Called also factor XI deficiency. The disease also occurs in cattle but the clinical disease is minor and it is inherited as a recessive character.
double hemophilia
dogs with both hemophilia A and hemophilia B have been produced experimentally.
vascular hemophilia
deficiency of clotting factor VIII and factor VIII-related antigen occurs in many breeds of dogs, particularly Doberman Pinschers, and in rabbits and pigs. See also von willebrand's disease.
vascular
pertaining to blood vessels or indicative of a copious blood supply.
vascular clamps
see hemostatic forceps.
vascular clip
see clip (1).
vascular disease
vascular grafts
see vascular conduit.
vascular hemophilia
von Willebrand's disease.
vascular malformation
includes hamartoma, arteriovenous fistula, telangiectasia.
vascular neoplasm
listed elsewhere; these include hemangioma, hemangioendothelioma, hamartoma, telangiectasia, angiokeratoma, juvenile bovine angiomatosis, bovine cutaneous angiomatosis, varicose scrotal tumor, meningioangioma, lymphomatoid granulomatosis, lymphangioma, glomangioma, hemangiosarcoma, lymphangiosarcoma.
vascular nevus
irregular shaped, cutaneous mass, congenital, hair-covered initially, subsequently hairless, usually 1-2 inches diameter in foals, may be inflamed, ulcerated; composed of densely packed blood vessels and bleed easily: most located on lower limbs; see also nevus.
vascular occlusive syndrome
complete occlusion of the vessel supplying blood to a part of the body causes temporary loss of function or death of the part, fall in temperature and change in color.
vascular plaque
a minor lesion in animals; manifested by slight thickening and wrinkling of the intima of the vessel over oval or elongated elevations.
vascular pole
the point on the renal glomerulus where the blood vessels enter and exit.
vascular prosthesis
see vascular conduit.
vascular ring anomaly
see vascular ring.
vascular sinus transformation
marked dilation of sinuses in lymph nodes because of blockage of drainage from the node.
vascular stasis
serious slowing, or complete cessation, of blood or lymph flow through vessels.
vascular system
the vessels of the body including aorta, arteries, arterioles, capillaries, venules, sinusoids, sinuses, veins, lymphatics.
vascular tone
the state of contractile tension in the vessel walls.
vascular tumor
see vascular neoplasm (above).
vascular tunic
of the eye; consists of the choroid coat, the ciliary body and the iris.
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