Any variant hemoglobin
that is present will be detected as glycated products.
Other IVD testing forms utilized in clinical hematology - histology, cytology, erythrocyte sedimentation rate (ESR), variant hemoglobin
screening, flow cytometry - are discrete product areas apart from core laboratory hematology, and represented largely by different companies.
This test should not be used to diagnose or monitor diabetes in patients with the hemoglobin variant hemoglobin
6) In a study of 5,136 HbA1c tests performed by one reference laboratory, 1,059 were shown to have a variant hemoglobin
when tested by HPLC.
A new information campaign of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, highlights the importance of using accurate methods to test hemoglobin A1C in people with diabetes who have sickle cell trait or other inherited forms of variant hemoglobin
Incidence of variant hemoglobin
(Hb) and increased fetal Hb concentrations and their effect on Hb A1c measurement in a Korean population.
HPLC was performed on a Variant hemoglobin
testing system with a standardized Hemoglobin [A.
phenotypes may account for differential erythropoiesis-stimulating agent dosing in African-American hemodialysis patients.
The variant hemoglobin
had decreased oxygen affinity but was clinically silent, and the patient had no evidence of hemolysis or anemia.
Expediting rare variant hemoglobin
characterization by combined HPLC/electrospray mass spectrometry.
2 Plus [TM] Glycohemoglobin Analyzer (Tosoh Medics), the Diama [TM] Analyzer System and a Variant Hemoglobin
Testing System (Bio-Rad Laboratories), the Imx [R] Glycated Hemoglobin assay (Abbott Laboratories), Diatrac/Paragon [R] Electrophoresis System (Beckman Instruments), Tinaquant II on an Hitachi 717 analyzer (Roche Diagnostics), and the DCA 2000 Analyzer (Bayer Corporation, Elkhart, IN).
The Bio-Rad Variant Hemoglobin
Testing System is an automated HPLC instrument that uses a minicartridge filled with a cation-exchange polymer material.