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variable region |
Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson | 0.02 sec. |
variable region, the part of an immunoglobulin in which the amino acid sequence can differ among molecules of that class of immunoglobulin. The variable region includes the antigen-binding site. Compare constant region. variable region the N-terminal portion of heavy and light chains of immunoglobulin molecules in which the amino acid sequence varies as a consequence of somatic mutation and recombination during ontogeny of B lymphocytes and also occurring after antigen exposure. The variable amino acid sequence which provides more than 107 different antibody molecules is responsible for the antigen-binding specificity. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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