valproic acid


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Related to valproic acid: Divalproex, Sodium valproate

valproic acid

 [val-pro´ik]
an anticonvulsant administered orally for the control of seizures, particularly absence seizures. Serious hepatotoxicity has occurred during valproic acid therapy, so that liver function tests should be performed periodically during treatment.

valproic acid

/val·pro·ic ac·id/ (-ik) an anticonvulsant used particularly for the control of absence seizures.

valproic acid

(văl-prō′ĭk)
n.
An anticonvulsive drug, C8H15NaO2, given orally and by injection to treat epilepsy.

valproic acid

[valprō′ik]
an anticonvulsant.
indications It is prescribed alone or in combination to treat complex partial seizures, absence seizures occurring alone or in combination with other types of seizures, mania associated with bipolar disorder, and migraine prophylaxis.
contraindications It is not recommended for use during pregnancy or lactation. Hepatic disease or dysfunction, urea cycle disorders, and known hypersensitivity to this drug prohibit its use.
adverse effects Among the more severe adverse effects are decreased platelet function and hepatotoxicity, and pancreatitis. GI disturbances are common. Alopecia, rash, headache, and insomnia also may occur. A sometimes fatal hyperammonemic encephalopathy has occurred in patients with known or suspected urea cycle disorders.

valproic acid

Depakote®, Divalproex, Valproate Neurology An anticonvulsant monotherapy for absence seizures, equivalent to carbamazepine for generalized tonic-clonic seizures Adverse effects Weight gain, hair loss, tremors Complications Pancreatitis, cholecystitis. See Seizures. Cf Carbamazepine.

valproic acid

An inhibitor of the enzyme histone deacetylase which helps to maintain HIV in a latent state in people treated with highly active retroviral therapy. Valproic acid. There is hope that this will prove effective in eradicating the virus. Valproic acid has been widely used as an ANTICONVULSANT drug used to prevent all kinds of epileptic seizures. The drug is on the WHO official list. A brand name is Convulex.

valproic acid

an anticonvulsant.
References in periodicals archive ?
Of this group, 15 patients had received multiple drug treatments for delirium and/or agitation prior to valproic acid use.
To assess the uptake and breakdown of valproic acid in living organisms, they gave the drug to obese mice with high blood sugar levels, fatty livers and rapid weight gain.
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).
Valproic acid was cleared by the US Food and Drug Administration in 1978 as an antiepileptic.
Treatment included initiation of multiple medications, with a final regimen consisting of valproic acid (1,500 mg/d), clozapine, benztropine, haloperidol, olanzapine, and propranolol.
The half-life is reduced with enzyme-inducing AEDs like the hydantoins and increased with valproic acid.
Concomitant administration of valproic acid and topiramate has been associated with hyperammonemia with and without encephalopathy.
In addition to providing a truer picture of the mortality risks of antipsychotics and valproic acid, the other advantage of the VA study is that it delineates the mortality risks for individual medications compared with no use at all.
Sold under brand names that include Depakene, Depakote and Stavzor, valproic acid is used to smooth out the mood swings of people with manic-depressive disorder and related conditions.
Pharmacy researchers combined amino acids (the building blocks of proteins) with the valporic acid, and this combination medicine significantly reduced the likelihood of valproic acid causing liver damage or ulcers.
Efforts are underway to further investigate the possible association between prenatal exposure to valproic acid and autism.
We recently saw a male patient with a history of bipolar disorder who developed the onset of acute diabetic ketoacidosis during treatment with olanzapine, valproic acid and venlafaxine.