In June 2011, the FDA issued an alert when interim results of this study found that at age 3 years, children exposed to
valproate had lower scores on cognitive tests, information that was added to the labels at that time.
Children of women who used
valproate during pregnancy had a higher risk of autism spectrum disorder and childhood autism compared with children of women who did not use
valproate," the researchers wrote.
The authors point out that other research has pointed to the potentially harmful effects of
valproate on the developing fetus, and that the findings of the current study back other preliminary research.
Sodium
valproate, hyperandrogenism and altered ovarian function in Indian women with epilepsy: a prospective study.
In 2010, he received travel support from Sanofi-Aventis, a manufacturer of
valproate.
The
valproate binding sites on plasma proteins are easily saturable, however, and at plasma
valproate concentrations modestly greater than the therapeutic maximum, the fraction of total
valproate bound to protein starts to decrease.
Fetal
valproate syndrome: is there a recognisable phenotype?
The new study is important because it's the largest to show a connection between
valproate and diminished IQ.
The primary objective of the extension phase was to assess the long-term safety and tolerability of ABILIFY in combination with lithium or
valproate.
While from the same chemical class as
valproate (e.
His GP has tried lithium and
valproate semi-sodium but he still has highs and lows and we are all suffering.
Depacon--sold as
valproate by generic drugmakers Abraxis Pharma and Bedford--was best for those with generalized onset seizures and difficult to classify cases, the British researchers said.
