A transmembrane protein that links plasma membranes of adjacent cells together in a Ca2+-dependent manner; aids in maintaining the rigidity of the cell layer.
[L. uva, bunch of grapes, + Mod. L. morula, dim. of L. morum, fr. G. moron, mulberry, + -in]
CDH1A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.