Administrations of higher doses of CTX produce severe urotoxicity with hemorrhagic cystitis on urinary bladder (Hutter et al.
Here we studied the effect of two naturally occurring isothiocyanates such as allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC), on the inhibition of cyclophosphamide-induced urotoxicity.
Determination of the effect of naturally occurring isothiocynates on CTX-induced urotoxicity
One of the major side effects of CTX administration is urotoxicity in which urinary bladder is severely affected with continued therapy.
somnifera, commonly known as 'Aswagandha' could effectively cure the urotoxicity induced by CTX administration (Davis and Kuttan, 2000).
Morphological, histopathological, biochemical and enzyme analysis showed that the naturally occurring isothiocyanates, AITC and PITC could alleviate the severe urotoxicity induced by CTX.