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uroporphyrinogen

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uroporphyrinogen /uro·por·phy·rin·o·gen/ (-por″fĭ-rin´o-jen) a porphyrinogen formed from porphobilinogen; it is a precursor of uroporphyrin and coproporphyrinogen.
u·ro·por·phy·rin·o·gen (yr-pôrf-rn-jn, -jn)
n.
Any of various porphyrins that can be converted to uroporphyrins.

uroporphyrinogen [u″ro-por″fĭ-rin´o-jen]
a porphyrinogen formed from porphobilinogen; it is a precursor of uroporphyrin and coproporphyrinogen.

uroporphyrinogen
a precursor of uroporphyrin and coproporphyrinogen.

uroporphyrinogen III
first tetrapyrrole compound in the pathway of porphyrin synthesis from combination of four porphobilinogen compounds via the action of uroporphyrinogen I synthetase and uroporphyrinogen III cosynthetase.
uroporphyrinogen III cosynthetase
an enzyme involved in the synthesis of uroporphyrinogen.
uroporphyrinogen isomerase
see uroporphyrinogen III cosynthetase (above).
uroporphyrinogen I synthetase
an enzyme involved in the synthesis of uroporphyrinogen.


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However, in the inherited form of the disease, which affects up to 20% of PCT patients, the condition arises from a mutation in the uroporphyrinogen decarboxylase gene, although environmental and chemical factors may trigger or exacerbate symptoms.
33) Dermatologic Manifestations Porphyria cutanea tarda Porphyria cutanea tarda (PCT) results from decreased activity of uroporphyrinogen decarboxylase.
These include aminolevulinate (ALA) dehydratase, porphobilinogen deaminase (hydroxymethylbilane synthase), and uroporphyrinogen decarboxylase in spleen and ALA synthase in liver.
 
 
 
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