III and E-cadherin were also detected (Fig.
130) Similarly, uroplakin
III has been shown to be of help in identif)ying secondary EMPD arising from a urothelial primary.
High expression of human uroplakin
la in urinary bladder transitional cell carcinoma.
Kerr, then at the Agriculture Department, attached the genetic sequence for human growth hormone to the uroplakin
gene promoter, which controls where and when the gene switches on.
5) Metastases from the urinary tract express thrombomodulin, uroplakin
III, CK7 and CK20.
is a group of transmembrane proteins that are widely regarded as urothelium-specific markers of terminal urothelial cytodifferentiation.
We also produced anti-human uroplakin
Ia antibody and showed its usefulness as a specific histologic marker because of its stable expression even in metastatic lesions (25).
Antibodies to uroplakin
III (UROIII), S100P, and GATA-3 have been shown to be urothelial-associated markers, while expression of CK14 and desmoglein-3 has been associated with squamous differentiation.
A panel of markers, including RCC marker, PAX2 or PAX8, uroplakin
III, thrombomodulin, and p63, can be helpful.
75) In a series of 99 tumors, genes typical of epithelial differentiation and encoding the cell-surface transmembrane proteins uroplakin
1B and 3B (UPK1B and UPK3B) and the protease kallikrein 11 (KLK11) were more highly expressed in epithelioid MM.
III (95,98-101) is 1 of the 4 members of the uroplakin
Stains for CK20, uroplakin
III, prostate-specific antigen, prostatic acid phosphatase, vimentin, S100, smooth muscle actin, chromogranin, synaptophysin, and glial fibrillary acidic protein were negative.