urokinase

urokinase /uro·ki·nase/ (UK) (u″ro-ki´nās) u-plasminogen activator; an enzyme in the urine of humans and other mammals, elaborated by the parenchymal cells of the human kidney and acting as a plasminogen activator. It is used as a therapeutic thrombolytic agent.

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u·ro·ki·nase (yr-kns, -nz)

n.

An enzyme that catalyzes the conversion of plasminogen to plasmin and is produced in the kidney, excreted in the urine, and used to dissolve blood clots. Also called plasminogen activator.

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urokinase

[yoo͡r′əkī′nās]

an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

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urokinase [u″ro-ki´nās]

u-plasminogen activator; the term is used particularly to denote a pharmaceutical preparation of the enzyme, administered intravenously as a thrombolytic agent in the treatment of acute coronary thrombosis and acute pulmonary embolism; also used to clear intravenous catheters of obstructions composed of clotted blood or fibrin deposits.

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urokinase (yoor´ōkī´nās),

n an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

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urokinase

an enzyme found in the urine of humans and other mammals which is secreted by kidney parenchymal cells and converts plasminogen to plasmin and activates the fibrinolytic system; used as a fibrinolytic agent.

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urokinase

A fibrinolytic enzyme involved in extracellular proteolysis; it is more active during cell migration and tissue remodeling, and cleaves fibronectin. See Kringle domain. Cf Streptokinase, Reteplase, tPA.