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uncoupler

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uncoupler
an agent that inhibits ATP synthesis by dissociating it from the electron transport system at one or more of the phosphorylation sites.


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When immune responses are overstimulated or essential systems compromised by metabolic uncoupler toxins or essential factor deficits, repair is deferred, tissue permeability increases, and the immune system can access and attack structural or cellular elements (see Table 4, p.
An uncoupler is able to dissipate the proton gradient over the inner mitochondrial membrane and thereby to reinitiate the electron and oxygen flow even when the mitochondrial ATPase is inhibited.
Salicylic acid is an uncoupler and inhibitor of mitochondrial electron transport.
 
 
 
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