The models tested included pure and partial competitive inhibition, non-competitive inhibition, mixed-type inhibition, and uncompetitive inhibition
2006) reverse Pgp-mediated MDR by uncompetitive inhibition
of substrate-Pgp association and inducing Pgp conformational changes.
Our data did not allow a distinction between competitive, noncompetitive, or uncompetitive inhibition
because of nonlinearity in the double reciprocal and Eadie-Hofstee plots.
The objective of the present study was the development of a quantitative liquid homogeneous immunoassay specific for theophylline based on the specific uncompetitive inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH) by mycophenolic acid (MPA).
Uncompetitive inhibition occurs when MPA combines with the IMPDH-XMP complex at the active site of the enzyme to form IMPDH-XMP-MPA complex, which is unable to release XMP.
Parallel slopes can be observed, indicating uncompetitive inhibition
by engeletin in the manner similar to astilbin.