unbound drug

unbound drug

Free drug Therapeutics The fraction of drug in serum that is not bound to a carrier protein or other molecule, which generally is pharmacologically active
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4 In malnourished patients with anorexia nervosa, hypoalbuminemia is common and, therefore, unbound drug concentration is higher.
Only the unbound drug--two per cent--can be filtered, so clearance by filtration is reduced, in comparison to an unbound drug.
Higher levels of unbound drug may exist due to hypoalbuminemia, competition for protein binding sites by uremic substances, and alterations in protein binding sites.
Because only unbound drug is pharmacologically active, it is useful to measure the free concentration when any of the above conditions are present.
This is important because only unbound drug molecules can exert a therapeutic effect in the body or undergo metabolism and excretion.
The common laboratory practice is to measure total phenytoin concentrations, which assumes that phenytoin protein binding is relatively constant, so that the concentration of the active unbound drug can be predicted from the total drug plasma concentration (2,3).
Disopyramide Monitor unbound drug concentrations in renal failure patients.
phenytoin, which is an anti-seizure medication), there may be more unbound drugs available in infants as compared to older patients when the same dosages are given.
SurModics' technology can provide a covalently bound crosslinked polymeric matrix on the surface of medical devices for use as a reservoir to incorporate unbound drugs.
1, 1990 CANCER RESEARCH that two LDL-bound injected drugs -- methotrexate and floxuridine -- successfully dodged the body's natural clearance mechanisms to circulate at least six times longer in the blood of rats than did unbound drugs.
SurModics' PhotoLink surface modification technology can provide a covalently bound crosslinked polymeric matrix on the surface of medical devices for use as a reservoir to incorporate unbound drugs.