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unbound drug

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unbound drug
Free drug Therapeutics The fraction of drug in serum that is not bound to a carrier protein or other molecule, which generally is pharmacologically active


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As plasma albumin concentrations decrease, so do concentrations of proteins available for binding, resulting in higher circulating amounts of free, unbound drug (5).
1, 1990 CANCER RESEARCH that two LDL-bound injected drugs -- methotrexate and floxuridine -- successfully dodged the body's natural clearance mechanisms to circulate at least six times longer in the blood of rats than did unbound drugs.
 
 
 
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