unbalanced translocation

un·bal·anced trans·lo·ca·tion

condition resulting from fertilization of a gamete containing a translocation chromosome by a normal gamete; if this abnormality is compatible with life, the individual would have 46 chromosomes but a segment of the translocation chromosome would be represented three times in each cell and a partial or complete trisomic state would exist.

un·bal·anced trans·lo·ca·tion

(ŭn-băl'ănst trans'lō-kā'shŭn)
Condition resulting from fertilization of a gamete containing a translocation chromosome by a normal gamete; if this abnormality is compatible with life, the person has 46 chromosomes but a segment of the translocation chromosome is represented three times in each cell and a partial or complete trisomic state exists.
References in periodicals archive ?
The male patient was diagnosed with a balanced three-way reciprocal translocation after his female partner suffered repeated miscarriages and an elective abortion due to the fact that the embryo was affected with an unbalanced translocation.
Should a structural rearrangement occur in repetitive sequences, this step would remove the actual event; however, we chose to implement this step here to emphasize that the putative fetal de novo unbalanced translocation for plasma C occurred in a background of unique sequences.
One with an unbalanced translocation (11 and 13) of maternal origin, a strictly genetic anomaly.
Three children with an unbalanced translocation resulting in partial Trisomy 8 and partial Monosomy 12 survived in this family, and all had dysmorphic features and severe intellectual handicap.
A karyotypic abnormality in SPENP has been described in a 43-year-old black woman; the abnormality consisted of an unbalanced translocation between chromosomes 13 and 17: der(17)t(13:17)(q14:p11).
A woman pregnant with a male fetus affected by an unbalanced translocation (46,XY, der(14;21)(q10;q10), + 21) was recruited with informed consent.
5) Abnormal segregation during meiosis can result in sperm with unbalanced translocations (i.
PGD for detection of aneuploidies and unbalanced translocations utilizes fluorescent in situ hybridization (FISH), in which a DNA probe that is coupled with a colored fluorescent marker is hybridized to the DNA in the test sample.
It detects extra chromosome 21 material present in cells with unbalanced translocations of chromosome 21, but does not identify the problem as a translocation.
Polyploidy, monosomy, and unbalanced translocations each accounted for fewer than 10% of cases.
PGD for detection of aneuploidies and unbalanced translocations utilizes fluorescent in situ hybridization (FISH) in which a DNA probe that is coupled with a colored fluorescent marker is hybridized to the DNA in the test sample.
The typical D-FISH pattern of positive cells consists of1 red signal, 1 green signal, and 2 fusion (yellow) signals, but other patterns with fusion signals may emerge in cases of variant or unbalanced translocations.