ubiquitin-proteasome system


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Related to ubiquitin-proteasome system: Ubiquitin proteasome pathway, Immunoproteasome, E3 Ubiquitin Ligase

ubiquitin-proteasome system (UPS),

a multicomponent system that identifies and degrades unwanted proteins in the cytoplasm of all cells; involved in cell growth and differentiation, DNA replication and repair, apoptosis, and stress and immune responses.
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KEY WORDS: ethanol metabolism; protein metabolism disorder; biochemical reaction property; tissue; injury; inflammation; alcohol dehydrogenases; cytochrome P450 2E1; AODR (alcohol and other drug related) injury; proteolysis; protease inhibitors; cytolysis; apoptosis; lysosome; coenzymes; physiological AODE (alcohol and other drug effects); ubiquitin-proteasome system
In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.
The ubiquitin-proteasome system mediates protein recycling by tagging abnormal or unwanted proteins within cells with the small protein ubiquitin.
Intracellular Protein Degradation: From a Vague Idea Through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting: Aaron Ciechanover

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