ubiquitin-proteasome system


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Related to ubiquitin-proteasome system: Ubiquitin proteasome pathway, Immunoproteasome, E3 Ubiquitin Ligase

ubiquitin-proteasome system (UPS),

a multicomponent system that identifies and degrades unwanted proteins in the cytoplasm of all cells; involved in cell growth and differentiation, DNA replication and repair, apoptosis, and stress and immune responses.
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References in periodicals archive ?
1] UCH: Ubiquitin carboxyl-terminal hydrolases UCHL1: Ubiquitin carboxyterminal hydrolase L1 UPS: Ubiquitin-proteasome system UPR: Unfolded protein response USP: Ubiquitin-specific proteases.
Bott, "The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution," Frontiers in Molecular Neuroscience, vol.
Heese, "The ubiquitin-proteasome system and molecular chaperone deregulation in Alzheimer's disease," Molecular Neurobiology, 2015.
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease," Proceedings of the National Academy of Sciences of the United States of America, vol.
Effects of Alcohol Consumption on the Ubiquitin-Proteasome System.
Excessive alcohol consumption can impair proteolysis mediated by the ubiquitin-proteasome system through several mechanisms.
Thus, in contrast to the lysosomal and ubiquitin-proteasome systems, which are inhibited by chronic alcohol consumption, the activity of the calpain system is enhanced by chronic alcohol consumption.
PI3K: phosphoinositide 3-kinase, Akt: protein kinase B, UPS: ubiquitin-proteasome system, mTOR: mammalian target of rapamycin, TNF-[alpha]: tumor necrosis factor-alpha, IGF-I: insulin-like growth factor-I, ATP: adenosine triphosphate, AMP: adenosine monophosphate, AMPK: AMP-activated protein kinase, NADPH oxidase: nicotinamide adenine dinucleotide phosphate-oxidase, and ROS: reactive oxygen species.
Aerobic exercise training upregulates skeletal muscle calpain and ubiquitin-proteasome systems in healthy mice," Journal of Applied Physiology, vol.
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy," Human Molecular Genetics, vol.
Oddo, "The ubiquitin-proteasome system in Alzheimer's disease," Journal of Cellular and Molecular Medicine, vol.
Tabrizi, "The ubiquitin-proteasome system in neurodegeneration," Antioxidants and Redox Signaling, vol.

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