tumour necrosis factor


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Related to tumour necrosis factor: Cytokines, Interleukins

tumour necrosis factor

Either of two molecules—TNF-alpha or -beta—which mediate shock and tumour-related cachexia. TNF-alpha (cachexin) has sequence homology with other biological response mediators, including lymphotoxin, interferons, interleukin-l and granulocyte-macrophage-colony-stimulating factor.
 
Cell roles
TNF-alpha is a multi-purpose molecule in the immune system: it is an endogenous pyrogen, induces apoptosis and inflammation, triggers the sepsis response by upregulating IL-1 and IL-6, and it inhibits tumourigenesis and viral replication. TNF-alpha misbehaviour is linked to Alzheimer's disease, cancer, depression and inflammatory bowel disease.

Toxicity
Fever, headache, hypotension, cachexia, chills, fatigue, anorexia and thrombocytopaenia.

Alternative oncology
Some providers of alternative healthcare believe that TNF can be used to stimulate the immune response in patients with immune suppression caused by chemotherapy and radiotherapy.

tumour necrosis factor

One of two related CYTOKINES capable of killing certain cancer cells and which also have regulatory functions on the immune system. Tumour necrosis factor is implicated in various inflammatory diseases including RHEUMATOID ARTHRITIS.
References in periodicals archive ?
Based on our data, we think miR-30d probably plays multiple roles, both in enhancing insulin production and in protecting cells from the inflammatory effects of tumour necrosis factor," the biologist added.
Primary biliary cirrhosis shows association with genetic polymorphism of tumour necrosis factor a promoter region.
GHENT, Belgium -- Ablynx, the pioneer in the discovery and development of Nanobodies([R]), a novel class of antibody-derived therapeutic proteins, has announced that they have entered into an exclusive research collaboration and license agreement with Wyeth Pharmaceuticals, a division of Wyeth (NYSE:WYE), to discover, develop and commercialise Nanobodies([R]) directed at the tumour necrosis factor alpha (TNF-[alpha]) protein and its receptors that target diseases in multiple therapeutic areas.

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