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tryptophan 2,3-dioxygenase

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tryptophan 2,3-dioxygenase
n.
An oxidoreductase whose concentration is regulated by hormones produced in the adrenal glands; it is present in the liver. Also called tryptophanase.


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Cirrhotic liver disease patients present with reduced activity of tryptophan 2,3-dioxygenase (22%), with subsequent increased free tryptophan and half-life, and decreased clearance.
With the switch from Th1 to Th2 immune response in schizophrenia, indoleamine 2,3-dioxygenase is inhibited while tryptophan 2,3-dioxygenase is overexpressed.
 
 
 
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