trypanosomiasis


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Related to trypanosomiasis: Chagas disease

trypanosomiasis

 [tri-pan″o-so-mi´ah-sis]
infection with trypanosomes.
African trypanosomiasis an often fatal disease of Africa caused by Trypanosoma gambiense or T. rhodesiense and involving the central nervous system. The parasites are transmitted to human beings from cattle or other animals by the bite of the tsetse fly. Usually the first symptom is inflammation at the site of the bite, appearing within 48 hours. Within several weeks the parasites invade the blood and lymph, and eventually they attack the central nervous system. Characteristic symptoms include intermittent fever, rapid heartbeat, and enlargement of the lymph nodes and spleen. In the advanced stage of the disease there are personality changes, apathy, sleepiness, disturbances of speech and gait, and severe emaciation.



Pharmacologic treatment should begin as soon as possible and is based on lab results and patient symptoms. suramin, pentamidine isethionate, and melarsoprol are the most common medications used. Pentamidine isethionate or suramin may be injected to remove parasites from the blood or lymph nodes before onset of disease, but the most effective preventive measure is eradication of the tsetse fly.
American trypanosomiasis (South American trypanosomiasis) a form found from the southern United States south into South America, caused by Trypanosoma cruzi; it is transmitted to humans from wild animals by means of the feces of a blood-sucking bug. The parasites multiply around the points of entry before entering the blood and eventually attacking the heart, brain, and other tissues. Called also Chagas' disease.



The acute form often attacks children. Early symptoms include swelling of the eyelids and the development of a hard, red, painful nodule on the skin. Enlargement of the lymph nodes, liver, and spleen occurs, along with inflammation of the heart muscle, psychic changes, and general debility. In adults the chronic form often resembles heart disease.

The control strategy suggested by the World Health Organization is to interrupt transmission of the disease by the vectors and to systematically screen blood donors. Preventive measures, such as the wearing of protective clothing and the use of insecticides, are of primary importance. Medication with antiprotozoal agents is usually effective when administered during the acute stage of infection.

try·pan·o·so·mi·a·sis

(tri-pan'ō-sō-mī'ă-sis, trip'ă-nō-),
Any disease caused by a trypanosome.
Synonym(s): trypanosomosis

trypanosomiasis

/try·pano·so·mi·a·sis/ (tri-pan″o-so-mi´ah-sis) infection with trypanosomes.
African trypanosomiasis  human trypanosomiasis endemic in areas of tropical Africa, due to infection with Trypanosoma gambiense (Gambian t.) or T. rhodesiense (Rhodesian t.); it is transmitted by the bite of species of Glossina (tsetse flies) and in advanced stage attacks the central nervous system, resulting in meningoencephalitis that leads to lethargy, tremors, convulsions, and eventually coma and death.
South American trypanosomiasis  Chagas' disease.

trypanosomiasis

(trĭ-păn′ə-sō-mī′ə-sĭs)
n. pl. trypanosomia·ses (-sēz′)
Infection with or disease caused by trypanosomes.

trypanosomiasis

[trip′ənō′sōmī′əsis]
Etymology: Gk, trypanon + soma + osis, condition
an infection by an organism of the Trypanosoma genus. Kinds of trypanosomiasis are African trypanosomiasis and Chagas' disease. Also called trypanosomal infection.

trypanosomiasis

(1) South American trypanosomiasis (Chagas disease). 
(2) African trypanosomiasis: 
• West African—chronic or Gambian trypanosomiasis caused by Trypanosoma brucei gambiense. 
• East African—acute or Rhodesian trypanosomiasis caused by Trypanosoma brucei rhodinense.

trypanosomiasis

See American trypanosomiasis.

try·pan·o·so·mi·a·sis

(trī-pan'ō-sŏ-mī'ă-sis)
Any disease caused by a trypanosome.
Synonym(s): trypanosomosis.

trypanosomiasis

In Africa, a disease of the nervous system caused by infection with the single-celled parasite Trypanosoma brucei . Commonly known as ‘sleeping sickness’ African trypanosomiasis features extensive brain inflammation with headache, loss of concentration, lassitude, a vacant expression, drooping eyelids and finally loss of all motivation so that the affected person may starve to death. Unless treated, the condition ends in seizures, coma and death. See also TSETSE FLY and CHAGAS DISEASE (South American trypanosomiasis).

Gambia,

country in West Africa, bordering North Atlantic Ocean and Senegal.
Gambian sleeping sickness - caused by parasite Trypanosoma brucei and transmitted through bite of an infected tsetse fly. Synonym(s): trypanosomiasis

trypanosomiasis

clinically a nondescript disease which may be peracute, acute or chronic. Called also nagana, mal de caderas and others. See also dourine, surra. The diagnosis is based on a positive blood smear and the presence of an insect vector, often a tsetse fly, or a history of mating in the case of dourine.

American trypanosomiasis
a disease of humans caused by infection with Trypanosoma cruzi.
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Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis.
Most Africans present with advanced cases of trypanosomiasis, which involves the CNS.
The results indicate that cattle trypanosomiasis is an important disease in the study areas with the exception of the Livestock Investigation and Breeding Centre, Raa'v.
The prevalence of adrenal insufficiency was 27% in a study of Ugandan patients with trypanosomiasis (8).
Trypanosomiasis and leishmaniasis are vector-transmitted parasitic diseases, caused by unicellular, flagellated protozoan organisms.
Immtech has advanced clinical programs that include new oral treatments for Pneumocystis pneumonia (PCP), malaria, and trypanosomiasis (African sleeping sickness), and a well defined, expanding library of compounds targeting Hepatitis C, fungal infections, and bacterial infections.
Around 60,000 people a year die as a result of African Trypanosomiasis, better known as sleeping sickness, which is transmitted by the fly.
This buffering effect conferred by biodiversity may also apply to other human infectious diseases such as West Nile encephalitis, cutaneous and visceral leishmaniasis, African trypanosomiasis, and Chagas disease (Ostfeld and Keesing 2000b).
DNDi s primary objective is to deliver 11 to 13 new treatments by 2018 for leishmaniasis, human African trypanosomiasis (sleeping sickness), Chagas disease, malaria, paediatric HIV, and specific helminth infections and to establish a strong R&D portfolio that addresses patients treatment needs and supports long term objectives.
NTDs designated by the WHO for control or elimination: Buruli ulcer, Chagas disease (American trypanosomiasis), cysticercosis/taeniasis, dengue/severe dengue, dracunculiasis (Guinea worm disease), echinococcosis, fascioliasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthiasis, trachoma, and yaws.
Thiruvananthapuram, June 24 ( ANI ): The Trypanosomiasis disease, which spreads through flies, is affecting several animals at the zoo here.
To the Editor: We describe a confirmed case of human African trypanosomiasis (HAT) in an expatriate returning to France from Gabon after a probable tsetse fly bite in the urban setting of Libreville.