tropical splenomegaly syndrome

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See hyperreactive malarious splenomegaly.

tropical splenomegaly syndrome

An idiopathic splenomegaly affecting malnourished children and adult ♀ in malaria-endemic regions–eg, New Guinea, Africa, which may be a defective immune response to P malariae Clinical Massive splenomegaly, asthenia, fatigue Lab ↑ IgM antibodies against P vivax, ↓ T-helper cells ↓ CD4:CD8 ratio Treatment Chloroquine

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