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triple response

   Also found in: Encyclopedia 0.01 sec.
triple response
n.
The triphasic response to the firm stroking of the skin characterized by sharply demarcated erythema, a brief blanching of the skin, and release of histamine from the mast cells, followed by arteriolar dilation causing an intense red flare that extends beyond the margins of the line of pressure, and ending with the appearance of a line wheal having the configuration of the original stroking.
triple response,
a triad of phenomena that occur in sequence after the intradermal injection of histamine. First, a red spot develops, spreading outward for a few millimeters, reaching its maximal size within 1 minute and then turning bluish. Next, a brighter red flush of color spreads slowly in an irregular flare around the original red spot. Finally, a wheal filled with fluid forms over the original spot. Also called triple response of Lewis.


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