The tricyclic trimipramine
in the treatment of subjective tinnitus.
Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine
106,107] The better quality study showed improvement in disability and tinnitus loudness with nortriptyline, while a study of trimipramine
showed no benefit.
Table 1 Psychotropics associated with constipation Class Medications Atypical antipsychotics Clozapine, risperidone Typical antipsychotics Chlorpromazine, haloperidol, pimozide, thioridazine, thiothixene, trifluoperazine Anticholinergics Benztropine, trihexyphenidyl Antidepressants Amitriptyline, clomipramine, doxepin, imipramine, nortriptyline, trimipramine
trazodone Dermatitis, pruritus Amitriptyline, doxepin, trimipramine
Diarrhea, IBS Amitriptyline, doxepin, paroxetine,
At the time, both anticholinergic and antihistaminic effects were thought to be responsible, but the later observation that trimipramine
inhibited Campy-lobacter pylori in vitro suggested an additional explanation.
Of all the drugs tested, only trimipramine
coadministration could modify the results, since its metabolite, the desmethyltrimipramine, has the same tR as the IS (18.
The TCAs identified in the 1985 NAMCS included amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protryptiline, trimipramine
, and a combination of amitriptyline and perphenazine.
4 Clobazam 4 Trimipramine
20 Clomipramine 10 Vitamin B1 3.
We made three misidentifications: pholcodine was erroneously reported for a codeine metabolite, imipramine for trimipramine
, and amphetamine instead of phentermine--all structurally related compounds with almost identical ultraviolet spectra and close retention times.