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trimetrexate glucuronate

   Also found in: Wikipedia 0.02 sec.
trimetrexate glucuronate (trī´mi-trek´sāt´),
n brand name: Neutrexin;
drug class: folate antogonist;
action: inhibits the enzyme dihydrofolate reductase, which leads to interference with deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein synthesis in the
Pneumocystis carinii organism;
uses: alternative therapy for
P. carinii pneumonia in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS).

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