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trimetrexate glucuronate |
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trimetrexate glucuronate (trī´mi-trek´sāt´), n brand name: Neutrexin; drug class: folate antogonist; action: inhibits the enzyme dihydrofolate reductase, which leads to interference with deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein synthesis in the Pneumocystis carinii organism; uses: alternative therapy for P. carinii pneumonia in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). trimetrexate glucuronate NeuTrexin® An antimetabolic lipophilic dihydrofolate reductase inhibitor–ie, antifolate structurally related to MTX, which is antineoplastic and antimicrobial; TG is approved for treating PCP when
Bactrim/Septra cannot be used in immunocompromised Pts, and in Pts with colorectal, gastric, and pancreatic CA, acute leukemia, osteosarcoma; it may enhance 5-FU effectiveness in 5-FU and leucovorin-based therapy, improving survival. Cf
Pneumocystis carinii pneumonia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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