trimetrexate glucuronate

trimetrexate glucuronate (trī´mi-trek´sāt´),

n brand name: Neutrexin;
drug class: folate antogonist;
action: inhibits the enzyme dihydrofolate reductase, which leads to interference with deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein synthesis in the
Pneumocystis carinii organism;
uses: alternative therapy for
P. carinii pneumonia in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS).