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trimetrexate

   Also found in: Acronyms, Wikipedia 0.01 sec.
trimetrexate /tri·me·trex·ate/ (tri″-mĕ-trek´sāt) a folic acid antagonist structurally related to methotrexate, used as the glucuronate salt, in combination with leukovorin, to treat pneumonia in AIDS.
trimetrexate [tri″-mĕ-trek´sāt]
a folic acid antagonist structurally related to methotrexate, used as the glucuronate salt, in combination with leucovorin, to treat Pneumocystis carinii pneumonia in acquired immunodeficiency syndrome, administered intravenously.

trimetrexate
an antifolate and an antineoplastic agent, similar to methotrexate. Also used in the treatment of toxoplasmosis and Pneumocystis infections.


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Next, the treatment options for PCP in these regions are often limited to TMP-SMX, since regimens such as pentamidine, clindamycin plus primaquine, trimetrexate, and atovaquone are unavailable.
If the patient has an allergy to sulfa drugs, alternative regimens include intravenous pentamidine, trimethoprim and dapsone, clindamycin and primaquine, or atovaquone and trimetrexate.
Trimetrexate glucuronate (with Leucovorin)(Neutrexin, TMTX), U.
 
 
 
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