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trimethoprim-sulfamethoxazole

   Also found in: Acronyms, Wikipedia 0.02 sec.
Trimethoprim-sulfamethoxazole (TMP-SMX)
An antibiotic used to treat and prevent PCP.

trimethoprim-sulfamethoxazole (trīmeth´prim´ sul´fmethok´s-zōl),
n a synthetic antibacterial combination effective in urinary tract infections; it is the drug of choice in the treatment of
Pneumocystis jiroveci pneumonia, one of the opportunistic infections associated with acquired immunodeficiency syndrome (AIDS).

trimethoprim-sulfamethoxazole
Bactrim®, Septra® A broad-spectrum combination antibacterial, formulated as a 1:20 ratio of T to S, which is effective in genitourinary, GI, and respiratory tract infections; it is the antibiotic of choice in PCP for which the failure rate of 5-20%; T-S is also effective against Salmonella, Shigella, Nocardia spp, H influenzae, Listeria monocytogenes, S pneumoniae, Isospora belli, and possibly Toxoplasma gondii; T-S is non-toxic in non-immunocompromised Pts; up to 60% of AIDS Pts have adverse effects–eg, ↑ LFTs, neutropenia, thrombocytopenia, erythematous maculo-papular rash, Stevens-Johnson syndrome, exfoliative dermatitis, N&V


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