Trimethoprim-sulfamethoxazole (TMP-SMX)
trimethoprim-sulfamethoxazole (trīmeth´
prim´ sul´fmethok´s-zōl),
trimethoprim-sulfamethoxazole
An antibiotic used to treat and prevent PCP.
Mentioned in: Pneumocystis Pneumonia
trimethoprim-sulfamethoxazole (trīmeth´
prim´ sul´fmethok´s-zōl),n a synthetic antibacterial combination effective in urinary tract infections; it is the drug of choice in the treatment of
Pneumocystis jiroveci pneumonia, one of the opportunistic infections associated with acquired immunodeficiency syndrome (AIDS).
Pneumocystis jiroveci pneumonia, one of the opportunistic infections associated with acquired immunodeficiency syndrome (AIDS).
trimethoprim-sulfamethoxazole
Bactrim®, Septra® A broad-spectrum combination antibacterial, formulated as a 1:20 ratio of T to S, which is effective in genitourinary, GI, and respiratory tract infections; it is
the antibiotic of choice in PCP for which the failure rate of 5-20%; T-S is also effective against Salmonella, Shigella, Nocardia spp, H influenzae, Listeria monocytogenes, S pneumoniae, Isospora
belli, and possibly Toxoplasma gondii; T-S is non-toxic in non-immunocompromised Pts; up to 60% of AIDS Pts have adverse effects–eg, ↑ LFTs, neutropenia, thrombocytopenia, erythematous maculo-papular rash, Stevens-Johnson
syndrome, exfoliative dermatitis, N&V
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