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trientine |
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trientine triethylenetetramine dihydrochloride; a copper-chelating agent used in the treatment of chronic hepatopathies in which copper accumulates. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Wilson's Disease is treated with lifelong use of D-penicillamine or trientine hydrochloride, drugs that help remove copper from tissue, or zinc acetate, which stops the intestines from absorbing copper and promotes copper excretion. In an 8-week double-blind trial, 54 patients were randomized to 20 mg of tetrathiomolybdate (TM) six times a day (three times with meals, three times between meals) or to 500 mg of trientine twice a day Neurologic status deteriorated in 1 of 27 patients on TM and 5 of 27 patients on trientine. Until recently, the two chelation-therapy drugs of choice were trientine and penicillamine. |
trientine |
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