tricyclic antidepressant


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tri·cyc·lic an·ti·de·pres·sant

a chemical group of antidepressant drugs that share a three-ringed nucleus.

tricyclic antidepressant

n. Abbr. TCA
Any of a group of antidepressant drugs, such as amitryptyline, that contain three fused benzene rings and that block the reuptake of the neurotransmitters norepinephrine and serotonin in the central nervous system.

tricyclic antidepressant (TCA)

any of a group of antidepressant drugs that contain three fused rings in their chemical structure and that potentiate the action of catecholamines. These drugs rapidly block the reuptake of amine neurotransmitters, but the exact mechanism of their effect is unknown because a period of time is required for the beneficial antidepressant effects to appear. The tricyclic antidepressants include a number of compounds, which may be grouped into four classes on the basis of chemical structure: dibenzazepines, dibenzocycloheptadienes, dibenzoxazepines, and dibenzoxepines. Besides their use to treat depression, various tricyclic antidepressants are used for other conditions, such as obsessive-compulsive disorder, panic disorder, and neurogenic pain.

tricyclic antidepressant

Pharmacology Any psychoactive dibenzozepine derivative–eg, which have 3 central rings and a short linear chain attached to the terminal nitrogen and are thus tertiary amines Lab TA levels correlate poorly with the clinical status, as circulating levels of the highly lipid-soluble TCA represent a minute portion of the body load, and TCA metabolites with similar clinical effects may not be measured Clinical, overdose Parasympathetic disease with anticholinergic effects–eg, mydriasis, xerostomia, urinary retention, ↓ peristalsis, cardiac disease–intractable myocardial depression, hypotension, ventricular tachycardia, fibrillation, or heart block and CNS disease–confusion, agitation, hallucinations, myoclonus, seizures, lethargy that may progress to coma and respiratory arrest Adverse effects Dry mouth, constipation, blurred vision, hyperthermia, weakness, fatigue, lethargy, insomnia, confusion, seizures, ↓ peristalsis, hypotension, coma. See Desipramine, Imipramine, Nortriptyline, Therapeutic drug monitoring, Tricyclic antidepressant suicide. Cf Fluoxetine, Monoamine oxidase inhibitors.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressant drugs that share a three-ringed nucleus.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressants that share three-ringed nucleus.
References in periodicals archive ?
Tricyclic antidepressants act primarily on sodium (fast) channels but also on delayed rectifier potassium (IKr) channels.
Tricyclic antidepressants are used far less frequently than they were 20 years ago, when it was estimated that they accounted for some 500,000 drug overdoses in the USA per year, with a mortality rate disproportionately higher than with other drug overdoses (1).
Tricyclic antidepressant overdose: clinical presentation and plasma levels.
There were 85 respondents taking both CNS stimulant and tricyclic antidepressant medication.
In a follow-up study in 2006 by McGill University, Toronto, researchers from the same research group failed to find significant evidence of the increased risk, but nonetheless saw differences between the two groups of tricyclic antidepressants, with the group of drugs originally suspected of carcinogenicity numerically associated with higher breast cancer risk.
Tricyclic antidepressants also have direct cardiotoxic effects, due to inhibition of [Na.
Furthermore, evidence of tricyclic antidepressant drugs could not be found in the urinary toxicology screening test.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 concerning CombinatoRx, the scope of its United States patent relating to tricyclic antidepressant and glucocorticosteriod combinations, including CRx-191, the timing of potential future patent issuances, its product candidate CRx-191 and its clinical potential, its plans for clinical, preclinical and formulation development of its product candidates, its business plans and its drug discovery technology.
Desipramine, a tricyclic antidepressant, is a treatment option for patients with functional gastrointestinal disorders.
The big difference between the treatment arms involved rates of unequivocal fitness to drive, which ranged from a high of around 50% in patients on mirtazapine, quetiapine, and reboxetine to 10% in those receiving a tricyclic antidepressant.
His first line for treating constant neuropathic pain is a tricyclic antidepressant or venlafaxine, followed by an anticonvulsant drug or bupropion.
We first addressed this issue in a study that compared neurodevelopmental measures in the preschool children of 80 women who had taken a tricyclic antidepressant during pregnancy, 55 women who had taken fluoxetine, and 84 women who had not taken any drug known to have adverse fetal effects.