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trichloroethanol

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
trichloroethanol
a metabolic product of chloral and an hypnotic and analgesic in its own right.
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2006) concludes that pending the evaluation of a number of additional structural hypotheses, such as enterohepatic recirculation, plasma binding, and flow--or diffusion-limited treatment of tissue distribution, rigorous application of PBPK modeling to risk assessment appears feasible at least for TCE and its major oxidative metabolites, trichloroacetic acid (TCA) and trichloroethanol.
Key scientific issues in the health risk assessment of ... by Scott, Cheryl Siegel / Environmental Health Perspectives
Subsequent important metabolic branch points include the production of trichloroethanol (TCOH) and trichloroacetic acid (TCA) from CHL/CH; the production of TCOH glucuronide (TCOG) and regeneration of CHL/CH from TCOH, and the N-acetylation versus bioactivation of S-dichlorovinyl-L-cysteine (DCVC).
Issues in the pharmacokinetics of trichloroethylene and its ... by Evans, Marina V. / Environmental Health Perspectives
Recent studies of trichloroethanol exploring an alternative hypothesis for kidney tumorigenesis have failed to establish the formation of formate as a key event for TCE-induced kidney tumors.
Key issues in the modes of action and effects of trichloroethylene ... by Keshava, Nagalakshmi / Environmental Health Perspectives
 
 
 
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