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An organophosphorus compound effective against immature and mature stages of Schistosoma haematobium, but ineffective against other species of Schistosoma in humans.
metrifonate. Also spelled trichlorphon.
metrifonateAn organophosphate that is an irreversible inhibitor of acetylcholinesterase. Metrifonate had some currency for treating Schistosoma haematobium schistosomiasis, but proved less effective than praziquantel and is thus no longer used for this indication. It was being developed for Alzheimer's dementia, but was withdrawn due to adverse effects (respiratory paralysis and defects in neuromuscular transmission).
an organophosphorus insecticide and anthelmintic, used in horses, often in combination with other anthelmintics, for treatment of endoparasites and cutaneous habronemiasis. Also used in dogs against whipworms and as a pour-on in cattle for control of warble flies. It is used in fishponds and commercial fish farms to control anchorworms, gill flukes and lice. Called also metrifonate.
an organophosphorus compound used as an anthelmintic. It is toxic for sheep at recommended dose rates and is also hazardous for cattle. In pregnant sows it causes congenital cerebellar agenesis in the piglets and has been associated with left laryngeal hypoplasia in young horses. A solution of the compound is unstable and should be discarded if not used on the same day as the metabolite is toxic.