tretinoin


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tretinoin

 [tret´ĭ-no″in]
the all-trans stereoisomer of retinoic acid, used topically for treatment of cases of acne vulgaris in which comedones, pustules, and papules predominate; it prevents comedo formation and suppresses keratin synthesis; common adverse effects are erythema and desquamation. It is also administered orally in treatment of acute promyelocytic leukemia.

tret·i·no·in

(tret'i-nō'in),
A keratolytic agent. See: retinoic acid.

tretinoin

/tret·i·noin/ (tret´ĭ-noin″) the all-trans stereoisomer of retinoic acid, used as a topical keratolytic in the treatment of acne vulgaris and disorders of keratinization and administered orally in the treatment of acute promyelocytic leukemia.

tretinoin

(trĕt′ĭ-noin′)
n.
An isomer of retinoic acid used topically to treat acne and to mitigate fine facial wrinkling and orally to treat one form of leukemia.

tretinoin

[tret′inō′in]
a retinoic acid derivative.
indications It is prescribed in the topical treatment of acne vulgaris and fine wrinkles and is administered orally for inducing remission in acute promyelocytic leukemia.
contraindications Known hypersensitivity to this drug or pregnancy prohibits its use.
adverse effects Among the more serious adverse effects of topical administration are photosensitivity and red, edematous, blistered, or crusted skin. Almost everybody taking the drug orally experiences some degree of weakness, fatigue, headache, and fever, but adverse effects are seldom reasons for discontinuing use of the drug.

tretinoin

A synthetic form of vitamin A used to treat acne, keratinisation (e.g., keratosis pilaris) and dermatitis. It also stimulates the immune system and is used to treat acute promyelocytic leukaemia. Retinoic acid is the naturally occurring form of the fat-soluble vitamin A, which is critical for the transportation of monosaccharides in glycoprotein synthesis, as occurs in the turnover of mucosal epithelia of the oral cavity and the respiratory and urinary tracts.

Toxicity
Skin blistering, crusting, headache, nausea, vomiting, vertigo.

tretinoin

all-trans-retinoic acid Dermatology A synthetic derivative of vitamin A used topically to reverse some of the effects of photoaging, both clinically–↓ skin wrinkling, improved skin texture and color and microscopically–↑ epidermal thickness, ↑ collagen and dermal vessels and 'erasing' epithelial atypia and dysplasia; tretinoin restores production of collagen I in photodamaged skin and lightens postinflammatory hyperpigmentation, it is also used for acne, keratinization, dermatitis, as a cancer preventive agent, and to induce terminal differentiation of acute promyelocytic leukemia, driving it into a mature nonproliferative state of remission Mechanism Unknown, possibly related to tretinoin's inhibition of collagenase, which degrades anchoring fibril collagen; tretinoin doubles the number of anchoring fibrils at the dermoepidermal junction Adverse effects Skin blistering, dry skin, bone pain, headache, N&V, vertigo, ↑ transferases, hyperhistaminemia. See Retinal, Retinoic acid, Vitamin A.

tretinoin

A RETINOID drug used to treat ACNE, scaly skin conditions such as ICHTHYOSIS, skin ageing and certain forms of LEUKAEMIA. Brand names are Retin-A, Retinova and Vesanoid.

Tretinoin

A drug that works by increasing the turnover (death and replacement) of skin cells.
Mentioned in: Acne

tret·i·no·in

(tret'i-nō'in)
A keratolytic agent.

tretinoin (vitamin A acid, retinoic acid),

n brand name: Retin-A;
drug class: vitamin A acid;
action: decreases cohesiveness of follicular epithelium, decreases microcomedone formation;
use: treatment of acne vulgaris.

tretinoin

the all-trans stereoisomer of retinoic acid, used in dermatology for the treatment of disorders of keratinization. It is a potent teratogen and must be used with great caution.

Patient discussion about tretinoin

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More discussions about tretinoin
References in periodicals archive ?
ReFissa should be used under medical supervision as an adjunct to a comprehensive skin care program that includes avoiding direct sunlight (by using protective clothing and sunscreens with a minimum SPF of 15) and using other moisturizing facial creams that do not contain tretinoin.
Tretinoin is a drug most commonly prescribed bydermatologists for topical treatment of acne.
Tretinoin, available in cream, gel and liquid form, requires a physician's prescription.
If you're applying tretinoin in the summer, you have to be careful because it makes your skin more sensitive to sunlight.
This inconvenient reaction became known as retinoid dermatitis, and is common to all the currently licensed topical retinoids, including tretinoin, isotretinoin, adapalene and tazarotene, although there is some intercompany discussion on which of these retinoids is the least irritating.
Sentetik A vitamini derivelerinden biri olan tretinoin stratum korneumu inceltir, epidermiste glikozaminoglikan depolanmasi yapar ve epidermal melanizasyonu azaltir.
They add that the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial was launched in 1998 to assess whether high-dose therapy with a cream containing one such retinoid, tretinoin, could prevent cancer.
The rate at which retinol is converted to tretinoin is slow, and varies greatly between individuals.
Horizon's presenters said: "In the dermatology department of the University of Manchester, they've been researching tretinoin for years.
If you are using a product with tretinoin, such as Retin-A or Renova, be especially vigilant about wearing sunscreen--you are more liable to sustain a sunburn.
3,4) Anomalies has been described with the maternal use of tretinoin cream, (5) but no external causative factors are readily apparent in this case.
There is good evidence to back the anti-ageing properties of Vitamin A derivative tretinoin (Retinova - prescription only), but I have yet to be shown such evidence for retinol-based creams.