treponema-immobilizing antibody

(redirected from treponemal antibody)

trep·o·ne·ma-im·mo·bi·liz·ing an·ti·bod·y

antibody, evoked during syphilitic infections, possessing specific affinity for Treponema pallidum; in the presence of complement immobilizes the organism.
References in periodicals archive ?
Diagnosis is confirmed with specific treponemal testing, such as with a fluorescent treponemal antibody absorption assay or the T pallidum particle agglutination test.
Abbreviations: CIA, chemiluminescence immunoassay; EIA, enzyme immunoassay; FTA-Abs, fluorescent treponemal antibody absorption test; RPR, rapid plasma reagin assay; TP-PA, Treponema pallidum particle agglutination assay.
The venereal disease research laboratory (VDRL) test and the fluorescent treponemal antibody absorption (FTA-ABS) test were carried out for all patients, which are conventionally requested to diagnose syphilis.
pallidum particle agglutination (TPPA) test, and the fluorescent treponemal antibody absorption (FTA-Abs) test.
Guidelines from the United States of America (USA) and Europe recommend a combination of two tests: the first one is a non treponemal (cardiolipin, reaginic) test, essentially Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin (RPR); and the second is a treponemal test, essentially TP haemagglutination assay (TPHA), TP particle agglutination, or the fluorescent treponemal antibody absorption (FTA-abs) test (3,4).
There are a number of automated treponemal antibody assays evaluated elsewhere, mostly with relatively high sensitivity and specificity (9-12).
This principle is followed in many of the screening tests: mammography before biopsy for breast cancer screening; RPR before treponemal antibody tests in syphilis; and ELISA followed by Western blot for testing of HIV However, this has not been the case in cervical cancer screening since the introduction of HPV reflex testing in 2004.
Specific treponemal antibody tests such as treponemal enzyme immunoassay (EIA), Treponema pallidum haemagglutination (TPHA) and fluorescent antibody absorption (FTA-abs) tests have higher sensitivity and specificity than the nontreponemal tests and are used as confirmatory tests for syphilis after a reactive nontreponemal test has been reported1-4.
In general, serology tests for syphilis can be divided into two categories namely non-treponemal antibody test and specific treponemal antibody test.
This should include a combination of molecular analysis, fluorescent treponemal antibody absorption (FTA-abs), TPHA measurement at a higher dilution (to counter the effect of possible hypergammaglobulinaemia), total IgG, and screening for autoimmune diseases with anti-nuclear factor measurement.
Traditional algorithms recommend a nontreponemal assay for screening followed by a treponemal antibody test for confirmation of any initially reactive samples (Figure 2a, page 32).
Fluorescent Treponemal Antibody test (FTA)/Fluorescent Treponemal Antibody Absorption (FTAABS): Due to the disadvantages outlined above, the TPI was largely replaced by FTA-ABS testing (19).