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transphosphorylation

   Also found in: Encyclopedia 0.01 sec.
transphosphorylation /trans·phos·phor·y·la·tion/ (trans″fos-for″ĭ-la´shun) the exchange of phosphate groups between organic phosphates, without their going through the stage of inorganic phosphates.
trans·phos·pho·ryl·a·tion (trns-fsfr--lshn)
n.
A reaction involving transfer of a phosphoric group from one compound to another.

transphosphorylation [trans″fos″for-ĭ-la´shun]
the exchange of phosphate groups between organic phosphates, without their going through the stage of inorganic phosphates.

transphosphorylation
the exchange of phosphate groups between organic phosphates, without their going through the stage of inorganic phosphates.


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Using site-directed mutagenesis, nine cysteine residues (675, 722, 748, 787, 866, 917, 961, 1094, and 1105), within JAK2 were individually and progressively mutated to serines and the effects of these mutations were tested in autophosphorylation and transphosphorylation assays.
Mutagenesis of a critical Lys882 residue to a glutamate residue abolished all evidence of kinase activity, confirming that the observed phosphorylation of Tyr-to-Phe mutants was not a transphosphorylation catalyzed by another kinase.
 
 
 
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