transmissible spongiform encephalopathy


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Related to transmissible spongiform encephalopathy: bovine spongiform encephalopathy

encephalopathy

 [en-sef″ah-lop´ah-the]
any degenerative disease of the brain.
AIDS encephalopathy HIV encephalopathy.
anoxic encephalopathy hypoxic encephalopathy.
biliary encephalopathy (bilirubin encephalopathy) kernicterus.
bovine spongiform encephalopathy a prion disease of adult cattle in the British Isles with neurologic symptoms. It is transmitted by feed containing protein in the form of meat and bone meal derived from infected animals. The etiologic agent is also the cause of new variant Creutzfeldt-Jakob disease. Called also mad cow disease.
boxer's encephalopathy (boxer's traumatic encephalopathy) a syndrome due to cumulative head blows absorbed in the boxing ring, characterized by slowing of mental function, occasional bouts of confusion, and scattered memory loss. It may progress to the more serious boxer's dementia. See also postconcussional syndrome.
dialysis encephalopathy a degenerative disease of the brain associated with longterm use of hemodialysis, marked by speech disorders and constant myoclonic jerks, progressing to global dementia.
hepatic encephalopathy a condition, usually occurring secondary to advanced liver disease, marked by disturbances of consciousness that may progress to deep coma (hepatic coma), psychiatric changes of varying degree, flapping tremor, and fetor hepaticus.
HIV encephalopathy (HIV-related encephalopathy) a progressive primary encephalopathy caused by infection with human immunodeficiency virus type I, manifested by a variety of cognitive, motor, and behavioral abnormalities. Called also AIDS encephalopathy.
hypernatremic encephalopathy a severe hemorrhagic encephalopathy induced by the hyperosmolarity accompanying hypernatremia and dehydration.
hypertensive encephalopathy a complex of cerebral phenomena such as headache, convulsions, and coma that occur in the course of malignant hypertension.
hypoxic encephalopathy encephalopathy caused by hypoxia from either decreased rate of blood flow or decreased oxygen content of arterial blood; mild cases cause temporary intellectual, visual, and motor disturbances, and severe cases can cause permanent brain damage within five minutes. Called also anoxic encephalopathy.
lead encephalopathy brain disease caused by lead poisoning.
mitochondrial encephalopathy encephalopathy associated with mitochondrial abnormalities, such as melas syndrome and merrf syndrome.
portal-systemic encephalopathy (portasystemic encephalopathy) hepatic encephalopathy.
progressive subcortical encephalopathy Schilder's disease.
subacute spongiform encephalopathy (transmissible spongiform encephalopathy) prion disease.
traumatic encephalopathy
Wernicke's encephalopathy a neurological disorder characterized by confusion, apathy, drowsiness, ataxia of gait, nystagmus, and ophthalmoplegia; it is due to thiamine deficiency, usually from chronic alcohol abuse. It is almost invariably accompanied by or followed by korsakoff's syndrome and frequently accompanied by other nutritional polyneuropathies. See also wernicke-korsakoff syndrome.

transmissible spongiform encephalopathy

n. Abbr. TSE
Any of a group of neurodegenerative diseases of humans and other animals, including scrapie, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease, that are thought to be caused by prions and can be transmitted by contact from one individual to another.

transmissible spongiform encephalopathy

a group of fatal neurodegenerative diseases that are unique in having either infectious or genetic causes. Examples include Creutzfeldt-Jakob disease and Gerstmann-Sträussler syndrome. A homozygous prion protein genotype predisposes individuals to susceptibility to the diseases.

transmissible spongiform encephalopathy

Encephalopathy marked by rapidly developing dementia or the sudden onset of psychiatric illnesses, often with myoclonus, ataxia, and aphasia. Death may occur within months of onset. These illnesses are believed to be caused by prions. Examples include kuru, mad cow disease (bovine spongiform encephalopathy), and Creutzfeldt-Jakob disease.
See also: encephalopathy
References in periodicals archive ?
Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cells.
Cattle sources of transmissible spongiform encephalopathy (TSE) used for experimental infections of C57BL/6 mice an transmission results * Cattle TSE isolate Age, y Breed Molecular type 1 8 Charolais H 2 12 Crossbreed H 3 4 Prim'Holstein Typical Survival periods (d) Cattle TSE in C57BL/6 mice Western blot isolate (mean [+ or -] SD) results ([dagger]) 1 702 [+ or -] 117 8/9 2 652 [+ or -] 85 10/10 3 511 [+ or -] 89 8/9 * SD, standard deviation.
Transmissible spongiform encephalopathy in greater kudu (Tragelaphus strepsiceros).
Senescence of the immune system function could interfere with transmissible spongiform encephalopathy pathogenesis in other ways as well, such as impairing migrating intestinal dendritic cells or complement pathways involved in complexing Pr[P.
After a 300-day incubation period, none of the hamsters (20) that received the filtered red cells developed scrapie, a transmissible spongiform encephalopathy.
Alternatively, if BSE originated from a spontaneous mutation in cattle, experimental studies of species susceptibility to this new strain of transmissible spongiform encephalopathy (TSE) had not sufficiently advanced to predict thai; humans would not be susceptible.
Once established, the new venture is expected to utilize ProMetic's platform technology and the ARC's expertise in Transmissible Spongiform Encephalopathy (TSE) research and pathogen clearance in blood products.
Its goal will be a Transmissible Spongiform Encephalopathy ("TSE") test, useful in the diagnosis of TSE diseases such as Bovine Spongiform Encephalopathy ("BSE") in cattle (commonly known as "mad-cow disease"), Scrapie in sheep, Chronic Wasting Disease ("CWD") in wild deer and elk and Creutzfeldt-Jakob Disease ("CJD") in humans.
Mad Cow and Chronic Wasting Disease, along with the always fatal human variant Creutzfeldt-Jakob Disease (nvCJD), are all allied forms of Transmissible Spongiform Encephalopathy, which is caused by Prion Disease.
Its primary goal will be a transmissible spongiform encephalopathy (TSE) test, useful in the diagnosis of TSE diseases such as bovine spongiform encephalopathy (BSE) in cattle, (commonly known as mad cow disease), scrapie in sheep, chronic wasting disease (CWD) in wild deer and elk and Creutzfeldt- Jakob Disease (CJD) in humans.
Hemopure is compatible with all blood types, stable both refrigerated and at room temperature for up to three years, and is purified through patented and proprietary techniques that are validated to remove potential contaminants, including infectious agents such as bacteria, viruses and transmissible spongiform encephalopathy (TSE) agents.

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