transient hypogammaglobulinemia of infancy

transient hypogammaglobulinemia of infancy

n.

A temporary form of primary immunodeficiency that occurs in infants usually within the first six months following birth and is associated with an increased susceptibility to bacterial infection.

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hypogammaglobulinemia [hi″po-gam″ah-glob″u-lin-e´me-ah]

abnormally low levels of all classes of immunoglobulins, associated with heightened susceptibility to infectious diseases; see also agammaglobulinemia, dysglobulinemia, and immunodeficiency.

common variable hypogammaglobulinemia common variable immunodeficiency.

physiologic hypogammaglobulinemia a normal period of hypogammaglobulinemia seen in all infants at about 5–6 months of age as the level of transplacentally acquired maternal immunoglobulins declines before endogenous immunoglobulin synthesis rises to normal levels.

transient hypogammaglobulinemia of infancy prolongation of the normal physiologic hypogammaglobulinemia of infancy caused by delayed development of endogenous immunoglobulin production and associated with increased susceptibility to infections.

X-linked hypogammaglobulinemia X-linked agammaglobulinemia.

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transient hypogammaglobulinemia of infancy

Pediatrics A prolongation or accentuation of the normal physiologic decline in serum Igs that normally occurs in the first 3-7 months of life; in THOI, Ig levels may not normalize for 2-3 yrs; antibody production is normal