transfusion-related acute lung injury


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transfusion-related acute lung injury

adult respiratory distress syndrome (ARDS) occurring within 4 hours of transfusion. The estimated frequency is 1 in 5000 transfusions and the mechanism remains poorly understood. The prognosis is much better than with most other cases of ARDS.
See also: adult respiratory distress syndrome.

transfusion-related acute lung injury (TRALI)

a syndrome seen in persons receiving transfusions, characterized by pulmonary edema, dyspnea, hypoxemia, hypotension, and fever; it is thought to be a reaction to antibodies or other components of the donor blood product. The blood transfusion must be immediately stopped. Patients need oxygen support, and in some cases the syndrome can be fatal.

transfusion-related acute lung injury

Transfusion medicine
1. A type of ARDS characterized by acute noncardiogenic pulmonary edema–pulmonary white-out–and hypoxia within 4 hrs of transfusing a blood product from a multiparous donor containing plasma with potent antigranulocytic antibodies. See Adult respiratory distress syndrome.
2. A nonimmune response to transfusion of packed RBCs, attributed to platelet-specific antibodies Clinical Severe thrombocytopenia–eg, < 10 x 109/L–5–10 days after packed RBCs in Pt sensitized by prior transfusion or pregnancy Management Steroids, IVIG Prognosis Spontaneous recovery. See Transfusion.

trans·fu·sion-re·lated a·cute lung in·ju·ry

(trans-fyūzhŭn-rē-lātĕd ă-kyūt lŭng injŭr-ē)
Adult respiratory distress syndrome (ARDS) occurring within 4 hours of transfusion; mechanism remains poorly understood. The prognosis is much better than with most other cases of ARDS.
References in periodicals archive ?
Soluble CD40-ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential co-factor in the development of transfusion-related acute lung injury.
Pulmonary injury from transfusion-related acute lung injury.
Pulmonary pathology of rapidly fatal transfusion-related acute lung injury reveals minimal evidence of diffuse alveolar damage or alveolar granulocyte infiltration.
Transfusion-related acute lung injury or acute chest syndrome of sickle disease?
Transfusion-related acute lung injury (TRALI) produces a clinical picture similar to that of adult respiratory distress syndrome, consisting of hypotension, fever, dyspnea, and tachycardia.
Monitor patients for reactions associated with IVIg treatment that might occur with Hizentra, including renal dysfunction/failure, thrombotic events, aseptic meningitis syndrome (AMS), hemolysis and transfusion-related acute lung injury (TRALI).
If transfusion-related acute lung injury is suspected, test product and patient for antineutrophil antibodies.
In addition to identifying bacterial contamination of platelets as a key priority, the Committee also addressed hemolytic transfusion reactions primarily due to errors and transfusion-related acute lung injury.

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