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transformation zone

   Also found in: Acronyms 0.01 sec.
transformation zone
Gynecology The area of actively maturing epithelium between the current squamocolumnar junction–SCJ and the original squamous epithelium Composition Intermingled squamous and columnar epithelium–squamous metaplasia, islands of columnar epithelium, gland openings, Nabothian cyst; > 90% of neoplasia arises from the TZ; cervical colposcopy is inadequate unless the TZ is fully visualized; its location varies in relation to the ectocervix and endocervix, related to Pt age and degree of squamous metaplasia. See CIN.


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Excisional techniques include cold knife conisation, laser conisation, and large loop excision of the transformation zone.
HPV causes the outer layer of normal cells of the cervical transformation zone (TZ) to be replaced by cancer cells.
Large loop excision of the transformation zone (LLETZ): a new method of management for women with cervical intraepithelial neoplasia.
 
 
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