Furthermore, although spontaneous resolution is possible through transepidermal elimination
of cyst products, cases may persist for years in the absence of treatment.
Elastosis perforans serpiginosa (EPS) results from changes in both elastic and collagen fibers within the dermis, resulting in a foreign body reaction with transepidermal elimination
Hair follicle aging is driven by transepidermal elimination
of stem cells via COL17A1 proteolysis," Science, 2016; 351 (6273): aad4395 DOI: 10.
The sections taken from the two sites show two evolving lesions including subepidermal blister with necrosis of epidermis at one site and healing lesion with evidence of transepidermal elimination
at the other site.
The abnormal presence of elastic fibers in the superficial dermis and the appearance of transepidermal elimination suggested a diagnosis of EPS.
The molecular mechanism as the basis of the transepidermal elimination of elastic fibers is poorly understood.
Elastotic material is often present between epidermal cells in the tips of elongated retia, and there may be transepidermal elimination of this material.
Finally, perforating disorders with transepidermal elimination of elastin (elastosis perforans serpiginosa, perforating folliculitis, perforating pseudoxanthoma elasticum) may resemble HLE, but these lesions contain neutrophils and histiocytes with fewer lymphocytes and typically do not demonstrate vacuolar interface changes (Figure 7, B).
leprae in the epidermis, their transepidermal elimination
and presence in epidermal washings in multibacillary patients, point towards the possible role of skin in spread of leprosy.
Pathologic analysis revealed extensive large and small dermal calcium deposits with fibrosis, epidermal hyperplasia and focal transepidermal elimination
of calcium consistent with ISC (Fig.
Occasionally, there may be spontaneous perforating lesions, with transepidermal elimination
of the fragmented elastic fibers.
The necrobiotic dermal collagen--and in some cases the cartilaginous matrix--is extruded through a crater-like defect in the epidermis; thus, CDNH is considered to be one of the transepidermal elimination