Elastotic material is often present between epidermal cells in the tips of elongated retia, and there may be transepidermal elimination
of this material.
Pathologic analysis revealed extensive large and small dermal calcium deposits with fibrosis, epidermal hyperplasia and focal transepidermal elimination
of calcium consistent with ISC (Fig.
The necrobiotic dermal collagen--and in some cases the cartilaginous matrix--is extruded through a crater-like defect in the epidermis; thus, CDNH is considered to be one of the transepidermal elimination