transducin


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trans·duc·in

(tranz-dū'sin),
A protein that binds guanine nucleotides (that is, a G protein), found in retinal rods and cones, that plays a major role in signal transduction; in vertebrate rod cells it acts as a link of the photolysis of rhodopsin to the activation of cGMP phosphodiesterase.

transducin

/trans·du·cin/ (trans-doo´sin) a G protein of the disk membrane of the retinal rods that interacts with activated rhodopsin and participates in the triggering of a nerve impulse in vision.

transducin

GDP/GTP-regulated protein, composed of three subunits designated α, β and γ, involved in the visual process. Photoactivated rhodopsin activates transducin to bind GTP, the transducin-GTP complex activates G-phosphodiesterase (G-PDE) by removing the inhibitory γ-subunit of G-PDE. The activated G-phosphodiesterase catalyzes the conversion of cGMP to GMP. Since the major action of cGMP is to open Na+-channels, the decrease in cGMP closes the Na+-channels leading to hyperpolarization of the nerve.
References in periodicals archive ?
Light-dependent compartmentalization of transducin in rod photoreceptors.
Expression of cone transducin, Gz alpha, and other G-protein alpha-subunits messenger ribonucleic acids in pancreatic islets.
Furthermore, light-dependent activation of cGMP phosphodiesterase in the retina was also demonstrated to be mediated by the G protein called transducin and now more often called Gt (see review ref.
Phosducin, a light-regulated phosphoprotein, binds to subunits of transducin, a transducer G protein (Lee et al.
Activation of pertussis toxin sensitive G-protein in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin by ethanol.
A photon hitting a single rhodopsin molecule might activate hundreds of transducin molecules.
Intrinsic biophysical monitors of transducin activation: UV-visible spectroscopy, light scattering and evanescent field techniques.
He goes on to describe the next two proteins in the bitter pathway, the G-protein transducin and a taste specific phosphodiesterase that is activated by transducin.
Specifically, PDC modulates visual phototransduction by binding with the [beta]- and [gamma]-subunits of the heterotrimeric G-protein (G[beta][gamma]) transducin (Kuo et al.
1] phase of factor 1 mitotic cell cycle Guanine nucleotide GNB2 signaling pathway binding protein (G protein), beta polypeptide 2 Keratin 13 KRT13 Intermediate filament Keratin 15 KRT15 Intermediate filament Laminin, alpha 3 LAMA3 Cell surface receptor Phosphoinositide- PIK3R1 Phosphatidylinositol 3-kinase, regulatory 3-kinase activity subunit, polypeptide 1 Protocadherin 1 PCDH1 Cell-cell signaling Transducin (beta)-like TBL1XR1 Regulation of 1X-linked receptor 1 transcription Vav 3 oncogene VAV3 Small GTPase-mediated signal transduction V-myc myelocytomatosis MYCL 1 Transcription factor viral oncogene homolog 1 activity Xeroderma pigmentosum, XPA Nucleotide-excision complementation group A repair [iAs.
Even within particular lineages, there are cases where the function of a G[alpha] protein may be difficult to predict based on the class to which it belongs: for example, taste receptors in vertebrates interact with gustducins, a family of G[alpha]; proteins related closely to the transducins expressed in rod and cone photoreceptors (McLaughlin et al.
The researchers were surprised at how much this new molecule looks like the transducins, G proteins in the eye's rods and cones, notes Robert F.