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transducin

   Also found in: Wikipedia 0.01 sec.
transducin /trans·du·cin/ (trans-doo´sin) a G protein of the disk membrane of the retinal rods that interacts with activated rhodopsin and participates in the triggering of a nerve impulse in vision.
transducin
GDP/GTP-regulated protein, composed of three subunits designated α, β and γ, involved in the visual process. Photoactivated rhodopsin activates transducin to bind GTP, the transducin-GTP complex activates G-phosphodiesterase (G-PDE) by removing the inhibitory γ-subunit of G-PDE. The activated G-phosphodiesterase catalyzes the conversion of cGMP to GMP. Since the major action of cGMP is to open Na+-channels, the decrease in cGMP closes the Na+-channels leading to hyperpolarization of the nerve.


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Phosducin is a light-regulated phosphoprotein which binds to subunits of transducin (Lee et al.
Activation of pertussis toxin sensitive G-protein in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin by ethanol.
A photon hitting a single rhodopsin molecule might activate hundreds of transducin molecules.
 
 
 
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