Light-dependent compartmentalization of transducin
in rod photoreceptors.
Expression of cone transducin
, Gz alpha, and other G-protein alpha-subunits messenger ribonucleic acids in pancreatic islets.
Furthermore, light-dependent activation of cGMP phosphodiesterase in the retina was also demonstrated to be mediated by the G protein called transducin
and now more often called Gt (see review ref.
Phosducin, a light-regulated phosphoprotein, binds to subunits of transducin
, a transducer G protein (Lee et al.
Activation of pertussis toxin sensitive G-protein in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin
A photon hitting a single rhodopsin molecule might activate hundreds of transducin
Intrinsic biophysical monitors of transducin
activation: UV-visible spectroscopy, light scattering and evanescent field techniques.
He goes on to describe the next two proteins in the bitter pathway, the G-protein transducin
and a taste specific phosphodiesterase that is activated by transducin
Specifically, PDC modulates visual phototransduction by binding with the [beta]- and [gamma]-subunits of the heterotrimeric G-protein (G[beta][gamma]) transducin
(Kuo et al.
1] phase of factor 1 mitotic cell cycle Guanine nucleotide GNB2 signaling pathway binding protein (G protein), beta polypeptide 2 Keratin 13 KRT13 Intermediate filament Keratin 15 KRT15 Intermediate filament Laminin, alpha 3 LAMA3 Cell surface receptor Phosphoinositide- PIK3R1 Phosphatidylinositol 3-kinase, regulatory 3-kinase activity subunit, polypeptide 1 Protocadherin 1 PCDH1 Cell-cell signaling Transducin
(beta)-like TBL1XR1 Regulation of 1X-linked receptor 1 transcription Vav 3 oncogene VAV3 Small GTPase-mediated signal transduction V-myc myelocytomatosis MYCL 1 Transcription factor viral oncogene homolog 1 activity Xeroderma pigmentosum, XPA Nucleotide-excision complementation group A repair [iAs.
Even within particular lineages, there are cases where the function of a G[alpha] protein may be difficult to predict based on the class to which it belongs: for example, taste receptors in vertebrates interact with gustducins, a family of G[alpha]; proteins related closely to the transducins
expressed in rod and cone photoreceptors (McLaughlin et al.
The researchers were surprised at how much this new molecule looks like the transducins
, G proteins in the eye's rods and cones, notes Robert F.