transcriptional coactivator

transcriptional coactivator

a cofactor that stimulates transcription by binding at particular sites on DNA.
See also: coactivator.
References in periodicals archive ?
17) Interestingly, STAT3 and Smad1 form a complex bridged by a transcriptional coactivator, p300 or CREB binding protein (CBP), and synergistically induce astrocytic gene expression.
We asked whether immunohistochemistry directed toward NF2 (merlin), LATS2, and their downstream effector YAP/TAZ (a complex of Yes-associated protein and transcriptional coactivator with PDZbinding motif) (6) could serve as adjunctive tests when a question of mesothelioma versus a benign reaction arises.
Materials and Methods: We utilized a rotary cell culture system (RCCS) to study the role of transcriptional coactivator with PDZ-binding motif (TAZ) in simulated MG.
The transcriptional coactivator peroxisome proliferator-activated receptor ?
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator pgc1-alpha.
For example, the key glucagon-responsive transcription factor CREB-regulated transcriptional coactivator 2
CBP is a general transcriptional coactivator that functions to regulate gene expression through interaction with various transcription factors, including CREB (Giordano and Avantaggiati 1999), Elk 1 (Janknecht and Nordheim 1996), c-Jun (Giordano and Avantaggiati 1999), and TBP (TATA box binding protein) (Goodman and Smolik 2000).
PGC-1[alpha] is a transcriptional coactivator that interacts with a broad range of transcriptional factors and nuclear receptors, increasing the probability of certain genes related to adipogenesis of being transcribed.
Washington, Mar 4 (ANI): Scientists have found that "knocking down" a gene called transcriptional coactivator PPARg coactivator-1b (PGC-1b) can protect mice on a diet loaded with high-fructose from insulin resistance.
sup][9],[10],[11] EYA has been extensively characterized as a transcriptional coactivator, which operates in association with Sine oculis (SO/SIX) proteins.
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1," The FASEB Journal, vol.
The peroxisome proliferator-activated receptor-gamma (PPAR[gamma]) family of transcriptional coactivators includes PPAR[gamma]-coactivator (PGC)-1 alpha (PGC-1[alpha]), PGC1[alpha], and the PGC-related coactivator, PRC.

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