transcription factor


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transcription factor

a specific protein required for the initiation of transcription by an RNA polymerase. Each polymerase has its own set of transcription factors.
References in periodicals archive ?
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.
The 3-hr transcription factor activation assays are reliable predictors of 14-day transformation outcomes in the JB6 model and of mouse skin tumor promotion.
There's also a possibility, says McIntosh, that NPS's kidney problems and glaucoma would be treatable if the defects turn out to be reversible and if scientists could compensate for the dearth of the key transcription factor.
This appeared to involve alterations in the nuclear function of GR as a transcription factor, because there were no effects on hormone-stimulated translocation of GR from the cytosol to the nucleus, yet arsenite was able to block GR-dependent induction of gene expression even when administered 2 hr after Dex stimulation.
The initial Marligen Transcription Factor Assay will be available in the second quarter directly from the company and from BioSource.
Acting as genetic light switches are proteins known as transcription factors, many of which physically latch onto DNA to exert their influence.
From the structure that could be seen when just a single transcription factor was added, the team extrapolated a picture of the entire middle layer, which, Kornberg said, enabled them to understand how the enzyme locates a gene along a stretch of DNA.
In particular, their novel multiplex transcription factor assays enable comprehensive profiling of the proteins that regulate the expression of all genes, and they are an important target for the development and screening of next generation therapeutics.
13 CELL that the new gene resembles the fruit fly gene for a transcription factor, which controls the activity of other genes.
In the study, Aurox researchers examined the behavior of the donor nucleus in nuclear transplant embryos and identified several nuclear defects, including assembly of the differentiated cell-specific structural protein, lamin A, enhanced content of pronuclei in TBP, a general transcription factor, and high resistance of DNA to DNAse, all of which may affect development of the embryo.
Since the early days of molecular genetics, researchers have predicted that each transcription factor controls a separate platoon of related genes.
The first application of its NEUGENE compounds, Resten-NG(TM), is designed to treat cancer, cardiovascular restenosis and other cell proliferation disorders by inhibiting the production of a cellular transcription factor, the oncogene c-myc.

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