transcription factor


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transcription factor

a specific protein required for the initiation of transcription by an RNA polymerase. Each polymerase has its own set of transcription factors.
References in periodicals archive ?
Like transcription factors, these genes turn on other stem cell genes and turn off those associated with different cell types.
Rosengart, a team of researchers showed that administration of a cocktail made of transcription factors Gata4, Mef2c and Tbx5 (GMT) resulted in less scar tissue, or fibrosis, and up to a 50 percent increase in cardiac function in small animal models of the disease.
This form of B-precursor acute lymphoblastic leukemia (B-ALL) features genetic changes to two transcription factors known as DUX4 and ERG, proteins that closely control the activities of other crucial genes in human blood cells.
The dataset provides abundant information on the sequences of transcription factor genes, which can be used for full-length cDNA cloning and functional studies.
According to the company, the transcription factor technology is one of its several patent families representing its second-generation technology for modifying the content of nicotine and other nicotinic alkaloids in the tobacco plant.
Noteworthy is that a single and the same transcription factor functions as both a repressor and an activator depending on the site of DNA binding relative to promoters.
Kang discovered that at least five of these genes could be regulated by a single transcription factor called GATA1.
In the study, the team focused on a transcription factor named ''snail,'' which plays an important role in cell growth and other functions.
This model of action is consistent with the ability of NS1 expression to prevent activation of transcription factors involved in the induction of IFN[alpha]/[beta] synthesis, including IRF3 (16).
Experiments designed to elucidate a possible relationship revealed that DES acting through the estrogen receptor is inhibiting Wnt7a and that this in turn results in a failure to maintain Wnt5a (another member of the Wnt gene family) and Hox10 and Hox11 (genes for transcription factors critical in early development).
The technique involves linking DNA from a cell with the transcription factor protein, then isolating the complex through a process called immunoprecipitation.
Auxin hormone receptors have been characterized and selective degradation of transcription factors via the ubiqutin-26S proteosome pathway is known to result from hormone binding but there is currently little understanding of how hormone reception leads to that accelerated transcription factor degradation or how this, in turn, alters developmental physiology.

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