transcobalamin


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transcobalamin

 [trans″ko-bal´ah-min]
either of two plasma proteins, transcobalamin I and transcobalamin II, that bind and transport cobalamins, including vitamin B12 (see vitamin). Deficiency of transcobalamin II results in failure of immunoglobulin production, megaloblastic anemia, granulocytopenia, thrombocytopenia, and intestinal villous atrophy, and is correctable by vitamin B12 therapy.

transcobalamin

/trans·co·bal·a·min/ (trans″ko-bal´ah-min) any of three plasma proteins (transcobalamins I, II, and III) that bind and transport cobalamin (vitamin B12). Abbreviated TC.

transcobalamin

a group of proteins (of intestinal cells) that bind to cyanocobalamin (vitamin B12) and transport it to other tissues.
References in periodicals archive ?
Megalin is an endocytic receptor with a high affinity for the Cbl transport protein transcobalamin II that can mediate Cbl cellular uptake through endocytosis of the transcobalamin II-Cbl complex [27].
18 Vitamin B12 levels may be reported as normal or elevated in myeloproliferative disorders liver disease congenital transcobalamin II deficiency intestinal bacterial overgrowth and antecedent administration of vitamin B12.
Carmel reported that the blacks have significantly higher cobalamin and transcobalamin (especially transcobalamin II) levels than whites do while the lowest levels were observed in India, Africa, and Pakistan (5).
3 Good syndrome is among the long list of immunodeficiency differentials which include immunodeficiency due toHIV/AIDS, X linked agammaglobulinaemia (XLA), Autosomal Recessive Agammaglobulinemia, Selective IgM Deficiency, Selective IgE Deficiency, Antibody Deficiency with Transcobalamin II Deficiency, Drug-Induced Antibody Deficiency, Interferon-a/IL-12 Pathway Deficiencies, Natural Killer Cell Deficiency, Phagocyte Killing Defects, Specific Granule Deficiency.
TCN2 encodes for transcobalamin II which binds and transports vitamin B12 into the cell (Regec et al.
Blood was collected at baseline for measurement of plasma vitamin B(12), transcobalamin (TC), holotranscobalamin (holoTC), methylmalonic acid (MMA), total homocysteine (tHcy), and serum folate.
gene deletions/polymorphisms) and ASDs, including reduced folate carrier (RFC); catechol-O-methyltransferase (COMT); transcobalamin II (TCN2); glutathione S-transferase M1 (GSTM1); glutathione S-transferase P1 (GSTP1); 5, 10-methylenetetrathydrofolate reductase (MTHFR); metal-regulatory transcription factor 1 (MTF1); and divalent metal ion transporter SLCllA3 (116, 114-117).
After three to four hours, the vitamin B12 appears in the blood carried on transcobalamin II.
Direct assay for cobalamin bound to transcobalamin (holo-trascobalamin) in serum.
The intrinsic-factor cobalamin complex enters the intestinal mucosal cells by receptor-mediated endoycytosis where cobalamin is released, which then binds to transcobalamin.
Increased leucocyte alkaline phosphatase and transcobalamin III in chronic myeloid leukaemia associated with lithium therapy.