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transcobalamin

   Also found in: Wikipedia 0.01 sec.
transcobalamin /trans·co·bal·a·min/ (trans″ko-bal´ah-min) any of three plasma proteins (transcobalamins I, II, and III) that bind and transport cobalamin (vitamin B12). Abbreviated TC.
trans·co·bal·a·min (trnsk-bl-mn)
n.
Any of a family of cobalamin-binding proteins, deficiencies of which have been associated with low serum cobalamin levels.

transcobalamin [trans″ko-bal´ah-min]
either of two plasma proteins, transcobalamin I and transcobalamin II, that bind and transport cobalamins, including vitamin B12 (see vitamin). Deficiency of transcobalamin II results in failure of immunoglobulin production, megaloblastic anemia, granulocytopenia, thrombocytopenia, and intestinal villous atrophy, and is correctable by vitamin B12 therapy.

transcobalamin
a group of proteins (of intestinal cells) that bind to cyanocobalamin (vitamin B12) and transport it to other tissues.


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After three to four hours, the vitamin B12 appears in the blood carried on transcobalamin II.
The intrinsic-factor cobalamin complex enters the intestinal mucosal cells by receptor-mediated endoycytosis where cobalamin is released, which then binds to transcobalamin.
Increased leucocyte alkaline phosphatase and transcobalamin III in chronic myeloid leukaemia associated with lithium therapy.
 
 
 
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