toxoid


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Related to toxoid: tetanus toxoid, diphtheria toxoid

toxoid

 [tok´soid]
a toxin treated by heat or chemical agent to destroy its deleterious properties without destroying its ability to combine with or stimulate the formation of antitoxin.
diphtheria toxoid a sterile preparation of formaldehyde-treated products of the growth of Corynebacterium diphtheriae, used as an active immunizing agent, generally in mixtures with tetanus toxoid and pertussis vaccine (DTP) or with tetanus toxoid alone (DT for pediatric use and Td, which contains less diphtheria toxoid, for adult use).
tetanus toxoid a sterile preparation of formaldehyde-treated products of the growth of Clostridium tetani, used as an active immunizing agent, either in mixtures with diphtheria toxoid and pertussis vaccine (DTP, DT, Td) or by itself (T).

tox·oid

(tok'soyd),
A toxin that has been treated (commonly with formaldehyde) so as to destroy its toxic property but retain its antigenicity, that is, its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity. For specific toxoids, see entries under vaccine
Synonym(s): anatoxin
[toxin + G. eidos, resemblance]

toxoid

/tox·oid/ (tok´soid) a modified or inactivated exotoxin that has lost toxicity but retains the ability to combine with, or stimulate the production of, antitoxin.
diphtheria toxoid  the formaldehyde-inactivated toxin of Corynebacterium diphtheriae, used as an active immunizing agent against diphtheria, usually in mixtures with tetanus toxoid and pertussis vaccine (DTP or DTaP) or with tetanus toxoid alone (DT for pediatric use and Td, which contains less diphtheria toxoid, for adult use).
tetanus toxoid  the formaldehyde-inactivated toxins of Clostridium tetani, used as an active immunizing agent, usually in mixtures with diphtheria toxoid and pertussis vaccine..

toxoid

(tŏk′soid′)
n.
A substance that has been treated to destroy its toxic properties but retains the capacity to stimulate production of antitoxins, used in immunization.

toxoid

[tok′soid]
Etymology: Gk, toxikon, poison, eidos, form
a toxin that has been treated with chemicals or heat to decrease its toxic effect but that retains its antigenic power. It is given to produce immunity by stimulating the creation of antibodies. See also toxin, vaccine.

toxoid

Immunology A bacterial toxin or other antigen treated with formaldehyde to ↓ toxicity while preserving antigenicity; toxoids are used to prepare diphtheria and tetanus vaccines. Cf Freund's adjuvant.

tox·oid

(tok'soyd)
A toxin that has been treated (commonly with formaldehyde) so as to destroy its toxic property but retain its antigenicity, i.e., its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity.
[toxin + G. eidos, resemblance]

toxoid

A bacterial toxin that has been chemically changed so as to lose its poisonous properties but retain its ability to stimulate antibody production. Toxoids make excellent vaccines against infections characterized by exotoxin production, such as DIPHTHERIA and TETANUS.

toxoid

a substance produced from a toxin but in which the toxicity is destroyed while the property of inducing immunity to the toxin is retained. Used to immunize against toxigenic infections, for example DIPHTHERIA and TETANUS.

Toxoid

A preparation made from inactivated exotoxin, used in immunization.
Mentioned in: Diphtheria

tox·oid

(tok'soyd)
Toxin that has been treated (commonly with formaldehyde) to destroy its toxic property but retain its antigenicity, i.e., its capability of stimulating the production of antitoxin antibodies and thus of producing an active immunity.
[toxin + G. eidos, resemblance]

toxoid

a toxin treated by heat or chemical agent to destroy its deleterious properties without destroying its antigenicity. Most of the clostridial diseases, e.g. tetanus, are controlled by vaccination with toxoids.
References in periodicals archive ?
Human chorionic gonadotropin (HCG) is a naturally occurring hormone necessary to sustain pregnancy The bishops said if the beta form of HCG is carried by a tetanus toxoid molecule and injected into a woman, it becomes an antigen that stimulates production of anti-HCG antibodies, which destroy the natural HCG.
b) If person is [greater than or equal to] 7 years of age, adult type tetanus-diphtheria toxoid (Td) is preferred to tetanus toxoid (TT) alone.
Thus, increasing the maternal tetanus toxoid coverage, an easier task, is vital.
5 ml dose of MassBiologics' Td is formulated to contain the following active ingredients: 2 Lf of tetanus toxoid and 2 Lf of diphtheria toxoid.
She reported on 314 pregnant women presenting to an academic perinatal center between March and June 2011 who answered an anonymous, multiple-choice questionnaire regarding their knowledge and opinions on vaccination in general, and Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis adsorbed) specifically.
Freelite[R] serum free light chain assays, IgG subclasses (IgGl - lgG4), IgG, IgA, IgA Subclasses (IgAl - lgA2), IgM, IgD, Albumin, 62-Microglobulin, CH50, Cystatin C, C3c, C4, Haptoglobin, Prealbumin, Tetanus toxoid plasma screen (RUO)
In two birth cohorts from the Faroe Islands, we recently found that the antibody response to diphtheria toxoid was significantly decreased at 18 months of age and, in an older cohort, that the tetanus toxoid antibody response was affected mainly at 7 years of age.
Bingham, director of the rheumatology clinics at John Hopkins University in Baltimore, reported that relative to patients treated with methotrexate only, patients who were given rituximab plus methotrexate mount a comparable recall response to tetanus toxoid, a measure of retained immunity.
In 2005, sanofi pasteur continued its tradition of innovation by introducing Menactra(R), Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine to protect against meningococcal disease in adolescents and adults, 11-55 years of age, and ADACEL(R), Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed as a booster dose for protection against tetanus, diphtheria and pertussis in both adolescents and adults 11-64 years of age.
Adult protection may be better than indicated by serosurveys and may have improved in the United Kingdom with use since 1994 of combined tetanus-diphtheria toxoid vaccine instead of tetanus toxoid for injuries (5).
However, tetanus toxoid is one of our safest and most effective immunizing agents.