toxic dose


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Related to toxic dose: lethal dose, effective dose

toxic dose (TD)

(in toxicology) the amount of a substance that may be expected to produce a toxic effect. See also median toxic dose.

toxic dose

TD50 Toxicology The calculated dose of a chemical introduced by a route other than inhalation, that would cause a specific toxic effect in 50% of a defined experimental animal population Cf Lethal concentration, Lethal dose.

tox·ic dose

(toksik dōs)
Minimal dose required to produce adverse effects.

dose

(dos) [Gr. dosis, a giving]
1. The amount of medicine or radiation administered.
2. The measurable exposure to an agent, e.g., to a poison, a quantity of radiation, or an irritant in the environment.

absorbed dose

1. Radiation absorbed dose.
2. The amount of a substance ingested, inhaled, or taken up through any protective surface into the body

air dose

The intensity of radiation measured in air at the target.

birth dose

Any dose, e.g., of a vaccine, administered to a neonate. The term is commonly used to describe a neonatal injection of hepatitis B vaccine.

bolus dose

A quantity of fluid or medicine given intravenously at a controlled, rapid rate.

booster dose

See: booster

collective dose

See: cumulative dose

cumulative dose

1. The total medication or radiation dose to which an organism is exposed after repeated treatments.
2. The total ionizing radiation dose resulting from repeated exposures to an occupationally exposed individual over a period of time. This dose can be calculated for whole-body acute exposure or for specific organs or body parts, e.g., the hands.
3. The amount of a drug present in the body after repeated doses.

curative dose

Abbreviation: CD
The dose required to heal an illness or disease.

depth dose

The actual amount of radiation exposure at a specific point below the surface of the body.

dialysis dose

The percentage by which blood urea nitrogen (BUN) is reduced during renal dialysis. Inadequate BUN reductions have been linked to increases in patient care costs, hospitalizations, and increased risk of death in patients with chronic renal failure. See: blood urea nitrogen

divided dose

Fractional portions of a dose administered at specified intervals. For example, a patient may be given 2 g of cephalexin daily, divided as 500 mg orally every 6 hr.

equianalgesic dose

A dose of one form of analgesic drug equivalent in pain-relieving effect to another analgesic. In pain control, this equivalence permits substitution of one analgesic to avoid undesired side effects from another.

equivalent dose

Abbreviation: HT
The biologically active dose of radiation. The damage that a particular absorbed radiation dose will have on living cells and tissues.

erythema dose

Minimal erythema dose.

fatal dose

A dose that kills.
See: median lethal dose

infective dose

The number of infectious organisms, esp. bacteria or viruses, that will cause disease in a healthy organism.

lethal dose

The dose of a substance that results in the death of cells, tissues, or the organism.

lethal dose low

Abbreviation: LDlo
The lowest dose of a substance that will kill at least one exposed organism.

maintenance dose

The dose required to sustain a desired effect.

maximum dose

The largest dose that is safe to administer.

maximum permissible dose

Abbreviation: MPD
The highest dose of radiation to which a person may be exposed over 1 year.

CAUTION!

Each U.S. state sets limits on exposure to ionizing radiation. For example, for an adult over 18, the MPD is typically 5 rem (50 mSv). For a pregnant female, the MPD is limited to 0.5 rem (5 mSv).

maximum tolerated dose

Abbreviation: MTD
The most extensive exposure to a treatment that a patient may receive before he or she experiences unbearable side effects.

mean marrow dose

Abbreviation: MMD
An estimated measure of average radiation exposure given to the blood-forming progenitor cells of the bone marrow, e.g., in whole body radiation treatment. The percentage of active bone marrow in the useful beam is multiplied by the average absorbed dose.

median curative dose

A dose that cures half of all treated patients.

median infective dose

Abbreviation: ID50
An infective dose that causes disease in half the subjects exposed to it.

median lethal dose

Abbreviation: LD50
The amount of a substance, bacterium, or toxin that will kill 50% of the animals exposed to it. Dose is usually calculated on amount of material given per gram or kilogram of body weight or amount per unit of body surface area.
See: minimum lethal dose

minimal erythema dose

, minimum erythema dose Abbreviation: MED
The shortest exposure to ultraviolet radiation that produces reddening of the skin within 1 to 6 hr and disappears in 24 hr. The minimal erythemal dose is used to calculate the duration of therapeutic exposure to ultraviolet light. For treatment using a “hot” ultraviolet lamp (UV-A or UV-B), the dose is calculated at a distance of 30 in. The minimal erythemal dose for “cold” ultraviolet (UV-C) is standardized at 30 to 38 sec at a distance of 1 in. Synonym: erythema dose; threshold dose See: table

CAUTION!

Burning, edema, and peeling occur at doses at or above the second degree erythemal dose.
DoseDescription
Suberythemal dose (SED)No erythema
Minimal erythemal dose (MED)Smallest dose that produces erythema within 1 to 6 hr and disappears within 24 hr
First degree erythemal dose (E1)Erythema lasts for 1 to 3 days. Some scaling of the skin is present. E1 is approximately 2.5 times the MED.
Second degree erythemal dose (E2)Erythema with associated edema, peeling, and pigmentation. E2 is approximately 5 times the MED.
Third degree erythemal dose (E3)Severe erythema and burning with associated blistering, peeling, and edema. E3 is approximately 10 times the MED.

minimum dose

The smallest effective dose.

minimum lethal dose

The smallest amount of a substance capable of producing death.
See: median lethal dose

nursing dose

1. The number of nurses in the work force divided by the population of the community at large.
2. The number of nurses available for clinical responsibilities, divided by the quantity of those duties.

percentage depth dose

In radiation therapy, the ratio of the absorbed dose at a given depth to the absorbed dose at a fixed reference depth. It is dependent on four factors: energy, depth, field size, and source-to-skin distance.

primary dose

An initial, large dose given to provide a high blood level as soon as possible.

radiation dose

1. Energy (joules) deposited by radiation in 1 kg of body tissue.
2. The exposure of a biological system to radiation, measured in rems or sieverts.
3. Radioactivity, measured in curies or becquerels.
4.
See: radiation absorbed dose

radiation absorbed dose

Abbreviation: rad
The quantity of ionizing radiation, measured in rad or gray (Gy), absorbed by any material, e.g., a person, per unit mass of matter. One Gy equals 100 rad.
Synonym: absorbed dose

shock dose

In cardioversion and defibrillation, the energy in joules selected to terminate an abnormal heart rhythm.

skin dose

A radiation dose to the skin including secondary radiation from backscatter.

sublethal dose

A dose containing not quite enough of a toxin or noxious substance to cause death.

stress dose

Stress dosage.

test dose

1. A low dose of a medication given to assess its safety or tolerability.
2. A small dose given to determine its precise effect on living tissues.

therapeutic dose

The dose required to produce the desired effect.

threshold dose

See: minimal erythema dose

tissue culture infective dose

Abbreviation: TCID50
The dose that will produce a cytopathic effect in 50% of the cultures inoculated.

tissue tolerance dose

The largest dose, esp. of radiation, that will not cause obvious or immediate disfunction in tissues.

tolerance dose

The dose of a drug or physical agent, e.g., radiation, that will not cause perceptible or immediate injury. This dose will vary among individuals.

toxic dose

A poisonous dose.

unit dose

A dose of medicine prepared in an individual packet for convenience, safety, or monitoring.
Synonym: monodose
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According to Selkirk, NCT scientists are using genomic and proteomic tools to identify the biochemical pathways corresponding to therapeutic and toxic doses.
In these studies, pretreatment with BNP7787 by either the oral or intravenous route followed by administration of otherwise toxic doses of either paclitaxel or cisplatin resulted in complete protection against nerve damage (as measured by changes in nerve conduction velocity).
We believe that S-8184 may have the ability to improve cancer therapy by delivering higher, more effective and less toxic doses of paclitaxel, and we are eager to confirm these potential benefits in further clinical studies.
The choice of such a high dose may raise doubts about the relevance of the biodisposition data in relation to lower and less toxic doses.
As a leading organization in the field of high-throughput and molecular toxicology, Phase-1 has identified 700 rat genes whose expression changes significantly and reproducibly as a function of toxic stimuli, and has utilized them to perform exhaustive gene expression studies for rats exposed to toxic doses of carefully selected compounds.
Paraplatin(R) (carboplatin), a currently available chemotherapeutic agent, demonstrated a similar amount of anti-tumor effect at toxic doses, whereas AG3340 inhibited growth at well-tolerated doses.