total-body irradiation

total-body irradiation

Radiation oncology RT to the entire body, usually followed by BMT or peripheral stem cell transplantation
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The authors used in their analyses the doubly weighted (via radiation and tissue weighting factors) hypothetical effective dose rate and effective dose related to total-body irradiation from sources outside the body.
When used in combination with other antioxidants including selenium, vitamin C, vitamin E, N-acetyl cysteine, and coenzyme Q10, lipoic acid helped improve survival of mice following total-body irradiation.
For example, when tumor cells are transplanted into the groins of mice, the rate of their metastasis into the lung is cut about in half by total-body irradiation with 15-30 cGy 12 days after the transplantation.
Total-body irradiation (TBI) has previously been shown to significantly increase progression-free survival when added to HDC followed by ASCT as compared to HDC alone.
Patients in the palifermin group received the FDA-approved dosing schedule, which consisted of an intravenous injection bolus of 60 mcg/kg per day for 3 days prior to total-body irradiation and chemotherapy and then for 3 days at the same dose immediately after transplantation of peripheral-blood hematopoietic stem cells.
In this multicenter study, researchers evaluated the outcomes of 68 adults with life-threatening hematologic disorders treated with intensive chemotherapy or total-body irradiation followed by HLA-mismatched umbilical cord blood transplants from unrelated donors (48 were mismatched for 2 or more HLA antigens).
Donnenberg and their colleagues at the Johns Hopkins Oncology Center in Baltimore exposed the patient to high-dose, total-body irradiation and chemotherapy, killing every kind of blood- and bone-marrow-derived cell known to harbor HIV.
Cyclophosphamide + Total-Body Irradiation + Autologous Stem Cell Transplantation - Drug Profile
We are deliberately reducing the total-body irradiation from the typical pre-bone marrow transplantation regimen doses of 1,200 to 1,500 centigray which is equivalent to being close to the epicenter of a nuclear bomb blast, to 200 centrigray," says Dr.
The standard approach to treating relapsed patients has been additional chemotherapy to achieve a second remission followed by very intensive treatment that could include "supralethal" chemotherapy, total-body irradiation (TBI), and hematopoietic stem cell transplantation.
A study completed last year in preclinical models conducted by the National Institutes of Health's (NIH), National Institute of Allergy and Infectious Diseases (NIAID), through a contract to the University of Maryland School of Medicine's Medical Countermeasures Against Radiological Threats (MCART) program, showed that AEOL 10150 can effectively increase regeneration of gastro-intestinal (GI) stem cells, reduce the severity and duration of diarrhea and improve survival when administered at 24 hours after doses of total-body irradiation that produce the lethal GI syndrome.
OTCBB: AOLS) announced today that recent experiments in preclinical models conducted by the National Institutes of Health's (NIH), National Institute of Allergy and Infectious Diseases (NIAID) Radiation/Nuclear Medical Countermeasure Development program have shown that AEOL 10150 can effectively increase regeneration of gastro-intestinal (GI) stem cells, reduce the severity and duration of diarrhea and improve survival when administered at 24 hours after doses of total-body irradiation that produce the lethal GI syndrome.