total-body irradiation

total-body irradiation

Radiation oncology RT to the entire body, usually followed by BMT or peripheral stem cell transplantation
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After these patients received total-body irradiation to destroy their own HSCs, they received donor HSCs from relatives or strangers.
Pathological examinations of bone marrow after total-body irradiation (at the 1 Gy and 2 Gy dose level) showed that hydrogen administration effectively ameliorated the radiation-induced reduction of bone marrow cells (Figure 4), while at the 0.
The authors used in their analyses the doubly weighted (via radiation and tissue weighting factors) hypothetical effective dose rate and effective dose related to total-body irradiation from sources outside the body.
Three analyses calculated the relative risk of BCC in patients who received radiation for tinea capitis or who underwent total-body irradiation before hematopoietic cell transplantation, they said.
When used in combination with other antioxidants including selenium, vitamin C, vitamin E, N-acetyl cysteine, and coenzyme Q10, lipoic acid helped improve survival of mice following total-body irradiation.
For example, when tumor cells are transplanted into the groins of mice, the rate of their metastasis into the lung is cut about in half by total-body irradiation with 15-30 cGy 12 days after the transplantation.
Patients in the palifermin group received the FDA-approved dosing schedule, which consisted of an intravenous injection bolus of 60 mcg/kg per day for 3 days prior to total-body irradiation and chemotherapy and then for 3 days at the same dose immediately after transplantation of peripheral-blood hematopoietic stem cells.
In this multicenter study, researchers evaluated the outcomes of 68 adults with life-threatening hematologic disorders treated with intensive chemotherapy or total-body irradiation followed by HLA-mismatched umbilical cord blood transplants from unrelated donors (48 were mismatched for 2 or more HLA antigens).
Donnenberg and their colleagues at the Johns Hopkins Oncology Center in Baltimore exposed the patient to high-dose, total-body irradiation and chemotherapy, killing every kind of blood- and bone-marrow-derived cell known to harbor HIV.
Complications are common during pretransplant conditioning, in which the patient undergoes highly cytotoxic chemotherapy combined with total-body irradiation or immunosuppressive agents to prepare for the infusion.