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total lymphoid irradiation

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.03 sec.
total lymphoid irradiation (TLI),
a method of inducing a strong immunosuppressive effect in patients undergoing bone marrow transplants, treatment of certain lymphomas, or other therapies requiring immunosuppression. TLI involves exposing all lymph nodes, the thymus, and spleen to a total of 2000 rad in 100-rad doses from a linear accelerator before graft implantation.

total lymphoid irradiation
Oncology Sequential radiation therapy to the 'mantle' and 'inverted Y' lymphoid regions, a combination of fields that may be used in extensive stage IV Hodgkin's disease and NHLs


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Cardiac transplant patients treated with total lymphoid irradiation for repeat rejection episodes appear to develop less coronary atherosclerosis than untreated recipients, according to data presented at the International Society for Heart and Lung Transplantation meeting held last month in Vancouver, Canada.
The trial was for TLI, total lymphoid irradiation, and involved the use of prednisone.
In the present study, reported in the April ANNALS OF INTERNAL MEDICINE, 24 arthritis patients for whom gold compounds and penicillamine treatments had failed were given--over six weeks-- either high-dose (2,000 rad) or low-dose (200 rad) total lymphoid irradiation.
 
 
 
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