total drug concentration

total drug concentration

Therapeutics The sum of unbound/free and protein-bound drug in the serum or plasma
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It has been shown that during CPB the unbound concentration of propofol is increased in response to reduced plasma binding, without any alteration in the total drug concentration (7).
In some cases, however, the total drug concentration may be misleading and a free drug concentration is needed.
The most appropriate sample for free drug analysis is serum, given the effects of some anticoagulants on either free fraction or total drug concentration (38).

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