total drug concentration

total drug concentration

Therapeutics The sum of unbound/free and protein-bound drug in the serum or plasma
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It has been shown that during CPB the unbound concentration of propofol is increased in response to reduced plasma binding, without any alteration in the total drug concentration (7).
The comparability of Intraject to the subcutaneous needle-injected sumatriptan product was established for pooled data across the three injection sites using standard bioequivalence criteria of peak concentration achieved in blood plasma (Cmax), and total drug concentration in blood plasma achieved over time (AUC).
In some cases, however, the total drug concentration may be misleading and a free drug concentration is needed.
The most appropriate sample for free drug analysis is serum, given the effects of some anticoagulants on either free fraction or total drug concentration (38).
The comparability of Intraject to the subcutaneous needle-injected sumatriptan product was established at all three injection sites using standard bioequivalence criteria of peak concentration achieved in blood plasma (Cmax), and total drug concentration in blood plasma achieved over time (AUC).

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