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topoisomerase inhibitors

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topoisomerase inhibitors,
a class of antineoplastic agents that interfere with the arrangement of DNA in cells.


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The difference in response to the two topoisomerase inhibitors can be explained on the basis of the mechanisms of strand cleavage induced by topoisomerase I and II and the repair pathways that overcome topoisomerase inhibition.
In cancer, cells rapidly divide in an uncontrolled manner and topoisomerase inhibitors can block this uncontrolled cell division.
20) In fact, one recent study surprised these scientists by disproving their hypothesis that topoisomerase inhibitors act like benzene in causing chromosome damage and Leukemia.
 
 
 
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