tonofilament


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ton·o·fil·a·ment

(ton'ō-fil'ă-ment),
A structural cytoplasmic protein, of a class known as intermediate filaments, bundles of which together form a tonofibril; a tonofilament is made up of a variable number of related proteins, keratins, and is found in all epithelial cells, but is particularly well developed in the epidermis.

tonofilament

[ton′ōfil′əmənt]
Etymology: Gk, tonos, stretching
a proteinaceous fiber found in epithelial cells. Bundles of tonofilaments form a tonofibril, which has a supporting function.

ton·o·fil·a·ment

(ton'ō-fil'ă-mĕnt)
A structural cytoplasmic protein, bundles of which together form a tonofibril; tonofilaments are made up of a variable number of related proteins, keratins, and are found in all epithelial cells.

tonofilament

(ton″ō-fil′ă-mĕnt) [ tono- + filament]
A bundle of intermediate filaments within a cell. They bind the pieces of the cytoskeleton to each other and to the cell membrane.
References in periodicals archive ?
5 The characteristic histological features of BIE hyperkeratosis with lysis and tonofilament clumping in granular layer keratinocytes are termed epidermolytic hyperkeratosis' and in some countries this term is also used to define the clinical picture.
For epithelioid mesotheliomas these include very long, thin apical microvilli that do not have a glycocalyx, as opposed to the generally shorter microvilli of adenocarcinomas that usually do have a glycocalyx; perinuclear tonofilament bundles; the presence of basal lamina; and long desmosomes.
For epithelioid mesotheliomas these include very long thin apical microvilli that do not have a glycocalyx, as opposed to the generally shorter microvilli of adenocarcinomas that usually do have a glycocalyx; perinuclear tonofilament bundles; the presence of basal lamina; and long desmosomes.
Electron microscopy shows the basaloid component to have desmosomes, rare tonofilaments and loose stellate granules or replicated basal lamina within the cystic spaces.
Apoptotic bodies rich in tonofilaments were not found.
The UTROSCTs have diverse findings under the electron microscope, including both epithelial (desmosome-like junctions, tonofilaments, lumina formation, and microvilli) and sex-cordlike features (nuclear indentation, abundant intracellular filaments, sparse to moderate rough endoplasmic reticulum [granulosa cells], and abundant intracytoplasmic lipid [Sertoli]), along with aggregates of perinuclear filaments with concordant IHC positivity for markers of epithelial and sex cord differentiation.
The finding of epithelial elements, mature desmosomes, and tonofilaments in the original neoplasm secured the diagnosis of spindle-cell squamous carcinoma.
Electron microscopic findings include lipid-like vacuoles in the corneocytes and granulocytes reduction in tonofilaments and irregular keratohyalin granules.
Prominent microvilli, desmosomes and tonofilaments if seen are highly suggestive of ATE (14).
Moreover, dividing cells are also connected to their neighbors with intercellular junctions and retain SLSs or short bundles of tonofilaments in their cytoplasm (Fig.
In the few studies where electron microscopy was used, some of the stromal cells had epithelial features, such as tonofilaments and intercellular junctions, similar to squamous epithelial cells.