Findings show that four of the seven first-time ITI patients achieved tolerization
in a median of 7.
23,24) This can be explained by the supposition that mechanisms of TLR and NOD tolerization
are different and that NOD responses are preserved in the face of TLR tolerization
Importantly, our study clearly emphasizes that physiologically relevant models that not only are human but which also resemble specific tissues are needed if we are to identify factors regulating immune activation and tolerization
, which in turn will aid the development of therapeutic interventions for allergy and inflammation, anti-cancer vaccines as well as improving diagnostics for skin and oral allergy.
Kang, "Intravenous tolerization
with type II collagen induces interleukin-4- and interleukin-10-producing CD4+ T cells," Immunology, vol.
Sensitization and tolerization
to brain antigens in stroke.
Analogy between the natural immune system principle and the developed system Natural Immune System Artificial Immune System applied in our context Self (antibody) Relevant trace Non-self (antigen) Irrelevant trace Lymphocyte (B- and T- cell) Detectors Detect the antigen Detect the irrelevant trace Tolerization
Negative selection mechanism Cloning and memorization Cloning and update the self-data Table 3.
The Rockefeller University patents licensed by NeoStem are entitled 'Methods for use of Apoptotic Cells to Deliver Antigen to Dendritic Cells for Induction or Tolerization
of T Cells'.
Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization
are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.
Standard protocol for management of atopic dermatitis includes avoidance of allergens (not practically feasible), hyposensitization (regime still to be standardized), systemic corticosteroids (response decreases with passage of time in some dogs and serious side effects in others), tolerization
(Muller et al.
to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis.
with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease.
Undenatured type II collagen administered orally works with the immune system to promote healthy joints by a process called oral tolerization