tolbutamide /tol·bu·ta·mide/ (tol-bu´tah-mīd) a sulfonylurea used as a hypoglycemic in the treatment of type 2 diabetes mellitus; the monosodium salt is used to test for insulinoma and diabetes mellitus.
TOLBUTamide
tolbutamide, (tolbū´t
mīd´),
tol·bu·ta·mide (t l-by  t -m d )n. An orally active hypoglycemic agent used in the treatment of adult-onset diabetes mellitus. |
TOLBUTamide
[tolbo̅o̅′təmīd]
an oral sulfonylurea antidiabetic.
indications It is prescribed in the treatment of stable Type 2 diabetes uncontrolled by diet alone and for some patients changing from insulin to oral therapy.
contraindications Unstable diabetes, serious impairment of renal, hepatic, or thyroid function, pregnancy, or known hypersensitivity to this drug or to other sulfonylurea medications prohibits its use.
adverse effects Among the more serious adverse effects are hypoglycemia and skin reactions. Blood dyscrasias may occur.
tolbutamide, (tolbū´t
mīd´),n brand name: Orinase;
drug class: sulfonylurea (first generation) oral antidiabetic;
action: causes functioning beta cells in pancreas to release insulin, leading to drop in blood glucose levels;
use: treatment of type II diabetes mellitus.
drug class: sulfonylurea (first generation) oral antidiabetic;
action: causes functioning beta cells in pancreas to release insulin, leading to drop in blood glucose levels;
use: treatment of type II diabetes mellitus.
tolbutamide
a first generation sulfonylurea derivative, used as an oral hypoglycemic agent in the treatment of diabetes mellitus.
tolbutamide tolerance test
the blood sugar curve after an intravenous injection of the hypoglycemic agent tolbutamide parallels the curve in a glucose tolerance test.
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